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- The drug troglitazone was used to treat diabetes but was withdrawn from the market when patientswho took the drug suffered from severe side effects. The data below show the activity of an enzymein the steroid biosynthetic pathway in the presence and absence of 10 µM troglitazone.[S] (µM) v0 (pmol min-1)Create a plot of 1/v0 vs. 1/[S]. Calculate KM and vmax in presence and absence of inhibitor. Whattype of inhibitor is troglitazone? Clearly support your answer.Lithium ion, which is used to treat bipolar disorder, interferes with the phosphoinositide signaling pathway by inhibiting enzymes such as inositol monophosphatase and inositol polyphosphate 1-phosphatase. Predict the eff ect of Li+ on the supply of cellular inositol, a precursor of phosphatidylinositol and PIP2.With the aid of diagrams describe the signalling pathway involving inositol 1,4,5 trisphosphate from ligand binding to intracellular effects (65%). In your answer explain how it is synthesised from the membrane phospholipid and, excluding receptor agonists, provide two examples of drugs that modulate activity in the pathway (35%).
- One such laboratory study investigated the binding of a hormone to three different receptor proteins in the cell membrane. The data collected are shown in the table below 1) Provide a brief explanation as to why ligand binding toproteins must be a reversible process. 2) Calculate the dissociation constant (Kd) for the hormone binding to each of the three proteins.260. A 42-year-old woman is found to have type 2 diabetes mellitus. The physician recommends treatment with exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist. Which of the following is most likely to occur as a result of the effect of GLP-1 on glucose homeostasis in the patient?a.Glucagon secretion in response to fastingB. Glucagon secretion in response to a mealC. Insulin secretion in response to fastingd. Insulin secretion in response to a mealDetermine the effect (either no effect, increase, or decrease) of the following: a. What is the effect of high cholesterol in the LDL receptor synthesis? Explain. b. What is the effect of intaking statin on the concentration of squalene? Explain.
- The metabolic precursor for the production of most eicosanoids isOne such laboratory study investigated the binding of a hormone to three different receptor proteins in the cell membrane. The data collected are shown in the table below: 1) Provide a brief explanation as to why ligand binding to proteins must be a reversible process. 2) Calculate the dissociation constant (Kd) for the hormone binding to each of the three proteins. 3) Which of the proteins demonstrate the tightest/strongest binding of the hormone? Which demonstrates the least tight binding of the hormone? What is the basis for your answer?Explain in detail the funcations and signalling and activation of ephrin receptor EPHB2. Give step by step explanation
- BIOC 384 G Protein-Coupled Receptor (GPCR) Signaling Q.7.3: Glucagon and epinephrine both signal stress, which would be low blood glucose levels or acute danger, respectively. Describe the upstream signaling pathways that would be activated in liver cells if you were hungry from a long hike in Sabino Canyon and came across the biggest rattlesnake you had ever seen right in front of you on the trail.The epinephrine-mediated “amplificationcascade” of Figure 24.14 has six steps, all of which are catalyticwith one exception. This cascade leads to the activation of glycogenphosphorylase. This enzyme acts in turn on glycogen to yieldglucose-1-phosphate (G-1-P).(a) Which step is not catalytic?(b) If each catalytic step had a turnover (molecules of substrateacted on per molecule of enzyme) of 10, how many moleculesof G-1-P would result from one molecule of epinephrine?(c) What is the biochemical advantage of such a cascade?(d) How is the amplification cascade of this questionreversed?Provide a diagram of the EPH RECEPTOR B2 (EPHB2) structure. Give annotations of binding sites and enzyme active sites.