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- For a lipid-soluble drug that has very poor aqueous solubility, what strategies could be used to make this drug more bioavailable after oral administration? This under Bipharmaceurics and Pharmacokinetics subject1. If excipients do not have pharmacodynamic activity, how do excipients affect the performance of the drug product? 2. What is meant by the rate-limiting step in drug bioavailability from a solid oral drug product? 3. What is the usual rate-limiting step for a poorly soluble and highly permeable drug (BCS 2)? 4. How could the manufacturing process affect drug product performance? 5. Drug absorption involves at least three distinct steps: dissolution, permeation, and disposition during transit in GI (an additional step of drug disposition in the body is involved as well for bioavailability). How are these processes validated in vitro when the in vivo requirement for drug bioavailability is waived? 6. What is meant by “sink” conditions? 7. What physical or chemical properties of a drug substance are important in designing a drug for (a) oral administration or (b) parenteral administration? 8. For a lipid-soluble drug that has very poor aqueous solubility, what strategies could be…4) A 45-year old woman weighing 68 kg is admitted to hospital after a drug overdose. A toxic plasma concentration of 264 mg/mL is recorded on admission. After 35 hours, a plasma concentration of 8.25mg/ml is recorded. Given this information, calculate the half life for this drug.(Assume the distribution is complete and that the elimination is described by a first-order process.)unit- hours
- Chemistry The patient in the previous example received 1000 mg of an antibiotic every 6 hours byrepetitive IV injection. The drug has an apparent volume of distribution of 20 L and anelimination half-life of 3 hours. Calculate:(a) the plasma drug concentration, Cp at 3 hours after the second dose(b) the steady-state plasma drug concentration, Cpss at 3 hours after the last dose (c) Cpmax(d) Cpmin(e) Cpaverage.What are the possible effects of taking multivitamin tablets to your overall health? Explain in terms of biochemistry.1. What physicochemical features facilitate (1) glomerular filtration, (2) drug secrecy, and (3) drug absorption in the kidney?
- Give typed full explanation How many milliliters of a 10,000 unit per 1 mL drug product should a nurse administer to a patient who is prescribed 5000 units of the drug?Bio The Agawam High School band is playing some lively marches while the coaches are giving pep talks to their respective football squads. Although it is September, it is unseasonably hot (88ºF/31ºC) and the band uniforms are wool. Suddenly, Harry the tuba player becomes light-headed and faints. Explain what happened.Give one advantage and one disadvantage of pharmaceutical solid dosage forms. Explain each advantage and disadvantage thoroughly.
- RNSG 1301 Pharmacology 3. The half- life of a medication is 60 minutes. What does this mean?Chemistry 4. A patient with febrile illness is instructed to administer metemizole sodium. This medication has an established dose of 25mg/kg/dose, the concentration of the drug is 1g/5ml. a) Calculate the dose to be administered and the dose volume for a patient weighing 6kg. b) Calculate the dose to be administered and the dose volume for a patient weighing 13kg.discuss how particle size affecting drug absorption ?