4) Describe in detail how p53 and MDM2 regulate cell division in a normal, healthy cell. You should describe 1) how these proteins cooperate to allow a cell to go through the cell cycle, 2) how they cooperate to stop the cell cycle, and 3) how they allow the cell cycle to continue again after having stopped it initially. You may use point form if you want.

4) Describe in detail how p53 and MDM2 regulate cell division in a normal, healthy cell. You should describe 1) how these proteins cooperate to allow a cell to go through the cell cycle, 2) how they cooperate to stop the cell cycle, and 3) how they allow the cell cycle to continue again after having stopped it initially. You may use point form if you want.

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter10: Cell Division And Mitosis

Section: Chapter Questions

Problem 1ITD: Biologists have long been interested in the effects of radiation on cells. In one experiment,...

See similar textbooks

Similar questions

Biologists have long been interested in the effects of radiation on cells. In one experiment, researchers examined the effect of radium on mitosis of chick embryo cells growing in culture. A population of experimental cells was examined under the microscope for the number of cells in telophase (as a measure of mitosis occurring) before, during, and after exposure to radium. The results are shown in the Figure. What is the effect of radium exposure on mitosis? Source: R. G. Canti and M. Donaldson. 1926. The effect of radium on mitosis in vitro. Proceedings of the Royal Society of London, Series B, Containing Papers of a Biological Character 100:413419.
Why is cell furrowing important in cell division? If cytokinesis did not occur, what would be the end result?
Scientists are able to isolate cells in various phases of the cell cycle. During an experiment in which Dr. Patrick McGroyn is causing cultured tumor cells to go through mitotic cell division, he isolates a group of cells that contain one and a half times more DNA than cells isolated in the G1 phase have. What phase must these cells be in? How do you know?
One important biological effect of a large dose of ionizing radiation (like X-rays) is to halt cell division. How does this occur? To answer this question, state the name and role of 2 specific and important proteins involved in the process. What happens if a cell has a mutation that prevents it from halting cell division after be irradiated? Be specific and detailed. An adult human who has reached maturity will die within a few days of receiving a radiation dose large enough to stop cell division. What does that tell you about cell division? In addition, name 2 different/unique cell types that would be primarily affected.
Name the two overarching phases of the cell cycle? How long does the complete cell cycle take in mammalian cells in culture ?
What are the four phases of the cell cycle? What is the principal activity in the cell during each phase? Can any phase be eliminated or bypassed?
If you were to look at a sample of “normal” cells, what phase of the cell cycle do you think most of the cells would be in? If you were to look at a sample of cancer cells, what phase of the cell cycle do you think most of the cells would be in?
Briefly explain: What is meant by the term “cycle” in cell cycle? What is happening in the S phase and M phase?
8. a. What are the four major stages of the cell cycle?b. Which stages are included in interphase?c. What events distinguish G1, S, and G2?
How can defects in the regulation of cell-cyle checkpoints would affect cells and explain how these defects relate to uncontrolled division in cancer and cancer progression? Describe the movements of chromosomes and the status of the microtubules spindle during interphase, prophase, metaphase, anaphase, and telophase? Explain the movement of chromosomes during stages of meoisis to produce sperm and eggs?
Under normal conditions, what happens to the cell cycle if the chromosomes fail to separate properly at anaphase?
1. A defective white blood cell does not complete the process of DNA replication. Which of the following is most likely to occur during the cell cycle for this cell? a. The white blood cell will be stopped at the G1 checkpoint and sent to the G0. b. The G2 checkpoint will stop the cell from continuing in the cell cycle. c. The white blood cell will get stuck at the spindle checkpoint. d.The cell will continue on to cytokinesis. 2. Which of the following statements describes how the RNA sequence specifies the production of an amino acid chain? a. Each set of three bases codes for an RNA molecule that specifies the anticodon. b. Each set of three bases codes for a single amino acid. c. Each base codes for one amino acid. d. Each group of three bases codes for an enzyme that binds amino acids together. 3. What will most likely happen when the -35 element and pribnow box are mutated? a. RNA Polymerase II will not be able to bind to the promoter region. b. Prokaryotic RNA…