4. In a parasite, C18:3 A6,9,12 and C18:4 A6,9,12,15 are available. These are modified C20:3 48,11,14 and C20:4 48,11,14,17, respectively. Downstream actions of enzymes generate C22:4 47,10,13,16 and C22:5 47,10,13,16,19, which are converted to final products C22:5 44,7,10,13,16 and C22:6 44,7,10,13,16,19 a. Draw out the pathways described above. Provide accurate line drawings for each lipid described b. For each step, identify if an elongase and/or desaturase is used. If a desaturase is used, indicate the type (for example A9 desaturase). c. For each step indicate whether the parasite could be using an enzyme from the human host to complete the step. Briefly justify your choices. d. This pathway is being considered as a parasite-specific target for drugs (to treat parasitic infections). Which step would you choose to target and why?

4. In a parasite, C18:3 A6,9,12 and C18:4 A6,9,12,15 are available. These are modified C20:3 48,11,14 and C20:4 48,11,14,17, respectively. Downstream actions of enzymes generate C22:4 47,10,13,16 and C22:5 47,10,13,16,19, which are converted to final products C22:5 44,7,10,13,16 and C22:6 44,7,10,13,16,19 a. Draw out the pathways described above. Provide accurate line drawings for each lipid described b. For each step, identify if an elongase and/or desaturase is used. If a desaturase is used, indicate the type (for example A9 desaturase). c. For each step indicate whether the parasite could be using an enzyme from the human host to complete the step. Briefly justify your choices. d. This pathway is being considered as a parasite-specific target for drugs (to treat parasitic infections). Which step would you choose to target and why?

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter7: Cellular Respiration: Harvesting Chemical Energy

Section: Chapter Questions

Problem 3TYK

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