49. The bioavailability of drug X after oral administration is 38%. Which of the following best explains this level of systemic bioavailability? A) Adipose distribution B) Hepatic metabolism OC) Plasma protein binding D) Pulmonary metabolism E) Renal metabolism
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- Explain the term first-pass eject or hepatic metabolism of the drug. What effect does first-pass have on drug bioavailability and activity?Why do the penicillin and cephalosporin groups of drugs have mildertoxicity than other antibiotics? What are their primary side effects?What are antimicrobial peptides?