5. During prolonged fasting, amino acids derived from muscle proteins and connective tissue become the main substrate for gluconcogenesis. How does glutamate enter the gluconcogenesis? For answer: a) write a reaction of the glutamate conversion into a-ketoglutarate, name the enzyme, indicate the energy effect of the reaction; b) draw a diagram for the a-ketoglutarate conversion to oxaloacetate and consequent including of OAA to gluconcogenesis, specify the reactions associated with ATP consumption; c) name the hormones that accelerate gluconcogenesis during fasting and regulatory enzymes of the process; and describe the mechanism of signal transduction by these hormones

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter25: Nitrogen Acquisition And Amino Acid Metabolism
Section: Chapter Questions
Problem 21P
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5. During prolonged fasting, amino acids derived from muscle proteins and
connective tissue become the main substrate for gluconcogenesis. How does
glutamate enter the gluconeogenesis? For answer:
a) write a reaction of the glutamate conversion into a-ketoglutarate, name the
enzyme, indicate the encrgy effect of the reaction;
b) draw a diagram for the a-ketoglutarate conversion to oxaloacetate and
consequent including of OAA to gluconcogenesis, specify the reactions
associated with ATP consumption;
c) name the hormones that accelerate gluconeogenesis during fasting and
regulatory enzymes of the process; and describe the mechanism of signal
transduction by these hormones.
Transcribed Image Text:5. During prolonged fasting, amino acids derived from muscle proteins and connective tissue become the main substrate for gluconcogenesis. How does glutamate enter the gluconeogenesis? For answer: a) write a reaction of the glutamate conversion into a-ketoglutarate, name the enzyme, indicate the encrgy effect of the reaction; b) draw a diagram for the a-ketoglutarate conversion to oxaloacetate and consequent including of OAA to gluconcogenesis, specify the reactions associated with ATP consumption; c) name the hormones that accelerate gluconeogenesis during fasting and regulatory enzymes of the process; and describe the mechanism of signal transduction by these hormones.
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