5. During prolonged fasting, amino acids derived from muscle proteins and connective tissue become the main substrate for gluconcogenesis. How does glutamate enter the gluconcogenesis? For answer: a) write a reaction of the glutamate conversion into a-ketoglutarate, name the enzyme, indicate the energy effect of the reaction; b) draw a diagram for the a-ketoglutarate conversion to oxaloacetate and consequent including of OAA to gluconcogenesis, specify the reactions associated with ATP consumption; c) name the hormones that accelerate gluconcogenesis during fasting and regulatory enzymes of the process; and describe the mechanism of signal transduction by these hormones
5. During prolonged fasting, amino acids derived from muscle proteins and connective tissue become the main substrate for gluconcogenesis. How does glutamate enter the gluconcogenesis? For answer: a) write a reaction of the glutamate conversion into a-ketoglutarate, name the enzyme, indicate the energy effect of the reaction; b) draw a diagram for the a-ketoglutarate conversion to oxaloacetate and consequent including of OAA to gluconcogenesis, specify the reactions associated with ATP consumption; c) name the hormones that accelerate gluconcogenesis during fasting and regulatory enzymes of the process; and describe the mechanism of signal transduction by these hormones
Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter25: Nitrogen Acquisition And Amino Acid Metabolism
Section: Chapter Questions
Problem 21P
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