5.Antimetabolites 5-fluorouracil and methotrexate are used for treatment of cancer. Explain the mechanism of their action. For this: aWrite the reactions inhibited by these drugs by formulas. Indicate enzymes, coenzymes. Represent the scheme ofregeneration ofrequired coenzyme, serving for transfer of one-carbon group b)Explain how the product of these reactions is used for further DNA replication. What other substrates are needed for this process? c)Write the reaction ofconvertion ofGDP todGDP. Specify the way of reduction of required specific protein. d) What

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