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- Assignment on KetohexosesConstruct the structure of the following enantiomers or mirror images:1. D and L Fructose2. D and L Allulose3. D and L Sorbose4. D and L TagatoseBIOMOLECULES - Please answer the questions properly. - Multiple choice 1. In human beings, what is the major control of de novo pyrimidine nucleotide synthesis? A. substrate availability B. feedback inhibition of glutamine-PRPP amidotransferase C. competitive inhibition of carbamoyl phosphate synthetase II D. availability of N-acetyl glutamate 2. In patients with Lesch Nyhan Syndrome, purine nucleotides are overproduced and over excreted. The hypoxanthine analogue Allopurinol, which effectively treats gout , has no effect on the severe neurological symptoms of Lesch- Nyhan patients because it does not? A. decrease de novo pyrimidine synthesis B. increase PRPP levels (Phosphoribosyl pyrophosphate) C. Decrease urate synthesis D. decrease de novo purine synthesisChymotrypsin information about enzyme? Trivial/Common Name Systematic (EC) name and number Chemical reaction catalyzed Metabolic pathway Function and cellular localization Size (kDa) and structure (tertiary and quaternary) pH stability Kinetic properties (Km- and Kcat value/s for natural substrates) Stability and potential inhibitors
- BIOMOLECULES - MULTIPLE CHOICE - Please answer properly QUESTION : In human beings, what is the major control of de novo pyrimidine nucleotide synthesis? A. substrate availability B. competitive inhibition of carbamoyl phosphate synthetase II C. feedback inhibition of glutamine-PRPP amidotransferase D. vailability of N-acetyl glutamateWorking at cross-purposes? Gluconeogenesis takes place during intense exercise, which seems counterintuitive. Why would an organism synthesize glucose and at the same time use glucose to generate energy?Straight or with a twist? Account for the different structures of glycogen and cellulose.
- 6. Cycle of tricarboxylic acids (TCA):• importance for cellular metabolism;• intracellular localization of TCA enzymes;• sequence of TCA reactions;• TCA enzymes and coenzymes;• substrate phosphorylation reactions in TCA;• decarboxylation reactions in TCA;• enzymes and coenzymes in dihydrogen reactions in TCA;• mechanisms of regulation of TCA.Why is the reaction rate low at pH7? Be specific and say something about the enzyme structure at the molecular level!Why bother to eat? What are the three primary uses for cellular energy?
- Serine protease enzyme mutation To show differences in the effect of the nucleophilic attack of the carbonyl group (C=O) of peptide bond between the catalytic triad of serine, histidine and aspartic acid, and another catalytic triad contains alanine, histidine and aspartic acid Provide/ draw an example of catalytic mechanism with catalytic triad contains alanine, histidine and aspartic Please answer completely will give rating surelyRECALL Which reaction or reactions that we have met in this chapter require ATP? Which reaction or reactions produce ATP? List the enzymes that catalyze the reactions that require and that produce ATP.Explaining the Stoichiometry of Fatty Acid Synthesis Carefully count and account for each of the atoms and charges in the equations for the synthesis of palmitoyl-CoA, the synthesis of malonyl-CoA, and the overall reaction for the synthesis of palmitoyl-CoA from acetyl-CoA.