6. For each of the drug molecules shown below, determine if it is an acidic drug molecule, a basic drug molecule, an amphoteric drug molecule, or a nonelectrolyte. -CF3 gujara H₂C Lomitapide CH3 HO НО, Pravastatin Drug Molecule Lomitapide Argatroban Pravastatin Amiloride Diltiazem COOH OH CH3 H₂N CF3 H NH₂ Amiloride ΝΗ H₂N NH₂ Acid/Base Character of Drug Molecule NH 0=5=0 NH H Argatroban COOH ""CH3 CH3 OCH3 CH₂N(CH3)2 Diltiazem CH3

Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter23: Amines
Section: Chapter Questions
Problem 23.31P
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2:52
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H₂3C
HO
6. For each of the drug molecules shown below, determine if it is an acidic drug molecule, a basic drug
molecule, an amphoteric drug molecule, or a nonelectrolyte.
-CF3
Lomitapide
Pravastatin
Drug Molecule
Lomitapide
Argatroban
Pravastatin
Amiloride
Diltiazem
null
COOH
OH
1.2 Identifying Acidic and Basic Functional Groups
H₂N
HO
NH
se sol och
CH₂
CH3
H₂N
NH₂
Amiloride
NH₂
……..
a
NH
Acid/Base Character of Drug Molecule
NH
Argatroban
COOH
CH3
CH3
OCH3
CH₂N(CH3)2
Diltiazem
CH3
Answers can be found in Section 2.2 [this will be linked to section 2.2 title]
Note: The questions in this chapter are related to Chapter 3 in Harrold MW and Zavod RM, Basic Concepts in
Medicinal Chemistry, American Society of Health-System Pharmacists, ©2013.
9
Transcribed Image Text:2:52 < Back H₂3C HO 6. For each of the drug molecules shown below, determine if it is an acidic drug molecule, a basic drug molecule, an amphoteric drug molecule, or a nonelectrolyte. -CF3 Lomitapide Pravastatin Drug Molecule Lomitapide Argatroban Pravastatin Amiloride Diltiazem null COOH OH 1.2 Identifying Acidic and Basic Functional Groups H₂N HO NH se sol och CH₂ CH3 H₂N NH₂ Amiloride NH₂ …….. a NH Acid/Base Character of Drug Molecule NH Argatroban COOH CH3 CH3 OCH3 CH₂N(CH3)2 Diltiazem CH3 Answers can be found in Section 2.2 [this will be linked to section 2.2 title] Note: The questions in this chapter are related to Chapter 3 in Harrold MW and Zavod RM, Basic Concepts in Medicinal Chemistry, American Society of Health-System Pharmacists, ©2013. 9
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