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- Match the following drug targets with the type of antibiotic that uses them (answers may be used more than once or not at all). a. Cell wall b.Cell membrane c. Protein synthesis (Transcription/Translation) d. Metabolic Pathway e. Nucleic Acid synthesis Chloramphenicol Clindamycin Erythromycin Doxycycline Sulfonamides Answer these multiple-choice questions as well. Please give just the answer and no explanation. 1. Which is not true of virus capsids?a. They surround and protect viral nucleic acidb. Always icosahedral in shapec. Remain outside of host bacterial cells while the nucleic acid is injected into the bacterial celld. Enters host animal cells together with the nucleic acid e. Made up of protein subunits called capsomeres 2. All viruses have: a. DNA b. RNAc. Envelopesd. Glycoprotein spikes e. Host specificity 3. Use the following to select the sequence of events during replication of DNA viruses in animal cells:1 = replication of viral nucleic acid2 = adsorption3…Can you please pick the right answer in each parentheses? The spike protein of SARS-CoV-2 is a carbohydrate-modified protein that ["bind the RNA genome of the virus", "", "is on the surface of the viral particle", ""] and plays a role in both ["replication of the viral genome", "recognition of host cell"] and ["packaging of viral genome for export", "fusion of viral envelope with host cell plasma membrane"] . Importantly, earlier work on spike proteins from other corona viruses showed that this molecule ["remarkable resistance to immune response", "shows remarkable conformational changes"] and only one of these served as a good antigen for vaccine development. A critical discovery in advancing the development of our current vaccines was determining what changes in the amino acid sequence would ["block degradation of the spike protein", "stabilize the conformation of the protein found on the viral particle"]. This…The rabies virus is a negative strand single stranded RNA virus, simply referred to as (-) ssRNA. Describe how this virus produce mRNA and replicates its genome.
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- Thank you!! a. What specific type of VECTOR will you use to perform your gene therapy? Please select from the following list of potential vectors: disabled retrovirus, adenovirus, adeno-associated virus (AAV), or herpes simplex virus (HSV), then give two reasons why this specific vector is the most appropriate for your gene therapy. Please explain why you were able to rule out the other potential vectors. NOTE: you MUST select a vector that is appropriate for this specific disorder and gene. b. What are two specific drawbacks, disadvantages, or risks associated with using this type of vector.(Please answer all parts, thank you!) 1) Mature red blood cells contain hemoglobin for transporting oxygen but contain little else. They lack a nucleus and most organelles. Are red blood cells more or less likely to be infected by a virus? a) More likely b) Less likely 2) How does SARS-COV-2 genetic material get replicated? a) Host cell DNA polymerase b) Host cell RNA polymerase c) RNA polymerase encoded for by viral genome and built in the host cell d) RNA polymerase encoded for by viral genome and originated from the virus 3) How does SARS-COV-2 proteins get built? a) The host cell's ribosome b) Ribosome encoded for by viral genome and built in host cellAnswer the following 1.Are viruses living or non-living organisms? 2. What is the difference between HIV and AIDS? 3. HIV is classified as a retrovirus. What are retroviruses? 4. In your own words, provide a short summary of the HIV replication cycle. 5. Why is reverse transcriptase an important enzyme in the replication cycle of HIV? 6. In the chapter about enzymes, we have discussed how drugs are basically inhibitors. There are currently a multitude of Antiretroviral therapy (ART or ARV) options available to people living with HIV (PLHIV) so that the viral replication is suppressed and does not progress to AIDS. What do you think these drugs target? Discuss briefly. 7. SARS-CoV-2, the virus that causes CoVid-19, belongs to the Coronaviridae family. Viruses under this family have a genome made of single-stranded positive-sense RNA. Is this similar to the viral genome of HIV? If so, do you think that – in theory – they would have similar replication cycles? 8. In your own opinion, do…
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