8 7 6 5 2 3 II I-1 1-2 2 1 2 3 4 5 6 7 8 [= II-1 11-2 11-4 II-5 11-6 II-7 II-8 11-3

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter5: Unit, Percentage, Milliequivalent, Ratio, And Household Measures
Section: Chapter Questions
Problem 2.2P
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A. Look at the pedigree, and DISREGARD individual II-8 for the moment. Is the pattern of inheritance of Unetan syndrome dominant or recessive?  You may assume that the gene is FULLY-PENETRANT in this family.  Please give two specific reasons that support your conclusion.

 

B. Now, looking at BOTH the pedigree AND at the Southern blot, is this trait autosomal, X-linked, or Y-linked? Please give two specific reasons that support your conclusion. Once again, disregard II-8 for the moment. One of your two reasons must refer specifically to evidence present in the Southern blot.

 

C. Define the gene alleles associated with Unetan syndrome. Your alleles MUST be consistent with the pattern of inheritance, AND your genetic notation must be consistent with that used throughout the course.

Unetan syndrome allele:  ________        Normal allele: ________  

Size
(kb)
(-)
8
7
6
5
4
3
2
1
(+)
II
1
I-1
1-2
N
1
II-1
II-2
N
3
II-3
O
4
11-4
5 6
II-6
II-5
O
7
11-7
8
II-8
Transcribed Image Text:Size (kb) (-) 8 7 6 5 4 3 2 1 (+) II 1 I-1 1-2 N 1 II-1 II-2 N 3 II-3 O 4 11-4 5 6 II-6 II-5 O 7 11-7 8 II-8
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