A 23-year-old man developed blurring of central vision in his left eye which later diagnosed as Leber’s Hereditary Optic Neuropathy. It is a genetic disease characterized by a mutation in mitochondrial DNA that produces a low activity of Complex I. It lowers the amount of energy available to the cells of the optic nerve and retina. These cells are damaged and even die because of lack of energy. 2a) List out the enzyme of citric acid cycle that is affected by this diseases.

A 23-year-old man developed blurring of central vision in his left eye which later diagnosed as Leber’s Hereditary Optic Neuropathy. It is a genetic disease characterized by a mutation in mitochondrial DNA that produces a low activity of Complex I. It lowers the amount of energy available to the cells of the optic nerve and retina. These cells are damaged and even die because of lack of energy. 2a) List out the enzyme of citric acid cycle that is affected by this diseases.

Anatomy & Physiology

1st Edition

ISBN:9781938168130

Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Chapter24: Metabolism And Nutrition

Section: Chapter Questions

Problem 32CTQ: Explain how glucose is metabolized to yield ATP.

See similar textbooks

Similar questions

18. Explain why the Krebs cycle can be referred to as the final common pathway of thedegradation of organic compounds.
Define the following terms: a. HETPP b. nucleoside diphosphate kinase c. amphibolic pathway d. anaplerotic reaction e. citric acid cycle
What would be the effect on an organism’s ability to use glucose as an energy source if a mutation inactivated glucose 6-phosphatase in the liver?
Describe the reactions catalyzed by nucleoside phosphorylase, adenosinedeaminase, and xanthine oxidase.
Considering that in aerobic respiration 38 atp is created and in anaerobic respiration 2 are created are large organisms more likely to be aerobic or anaerobic?Describe the process of transcription and its role in gene expression .Why is the citric acid cycle =krebs cycle=tca cycle called a cycle is O2 used directly in the krebs cycle? What is an oxidized product of the Krebs cycle name 2 reduced products released from the krebs cycle.
Leigh syndrome is characterized by psychomotor regression: that is, the progressive loss of mental andmovement abilities. Patients also suffer from lacticacidosis, a condition in which mitochondrial respiration is deficient, so their tissues metabolize glucoseanaerobically, leading to the buildup of lactate. Somepatients with Leigh syndrome have a mutation in themitochondrial gene MT-CO3, which encodes a subunit of the electron transport complex cytochromec oxidase. Other patients diagnosed with Leigh syndrome have a loss-of-function mutation in the nucleargene SURF1, which encodes a factor needed for theassembly of this same enzyme complex.a. How can the same symptoms result from mutationsin a mitochondrial gene and from mutations in anuclear gene?
draw the mechanism for step 3 of the citric acid cycle.?
a) What is the reason for the non-oxidative phase of the pentose phosphate pathway?b) Which compound is converted into which compound in the step where sequential dehydration and hydration reactions occur in the citric acid cycle?c) Why is ammonia released in some tissues carried by binding to other molecules in the blood? Where is it transmitted in the body for its destruction? What molecule is it transferred onto there? So what molecule does it make?
Which reactions of the citric acid cycle transfer energy as FADH2?
A genetic disease called glucose-6-phosphate dehydrogenase deficiency is inherited in a manner similar to that of sickle-cell anemia except that it occurs most frequently in males. The defective enzyme cannot keep erythrocytes supplied with sufficient amounts of the antioxidant molecule NADPH NADPH protects cell membranes and other cellular structures from oxidation. Describe in general terms the inheritance pattern of this molecular disease. Why do you think that the antimalarial drug primaquine, which stimulates peroxide formation, results in devastating cases of hemolytic anemia in carriers of the defective gene? Does it surprise you that this genetic anomaly is commonly found in African and Mediterranean populations?
Where are the enzymes of Krebs cycle located?
______________ transfers carnitine from mitochondrial matrix to cytoplasm during the transport of fatty acid to mitochondria. Carnitine acyltransferase I CarnitineacyltransferaseII Transaminase Translocase Citric acid shuttle