A 3-year-old girl was admitted with a diagnosis of acute lymphocytic leukemia. After admission, she was treated by administration of packed red cells, 2 units of platelets, IV fluids, and allopurinol. On the second hospital day, chemotherapy was begun, using IV vincristine and prednisone and intrathecal injections of methotrexate, prednisone, and cytosine arabinoside. She was discharged for home care 5 days later. She was continued on prednisone and allopurinol at home. She received additional chemotherapy 1 month later (11/1) and again on 11/14. On 12/6, she was readmitted because she had painful sores in her mouth and was unable to eat. LABORATORY RESULTS 10/1 10/2 10/3 10/4 11/14 12/6 6/20 Urea N 12.0 ** ** 15 4.0 2.0 ** (mg/dL) Creatinine 0.7 (mg/dL) ** ** 1.0 0.7 ** 0.7 Uric acid 12.0 9.2 4.0 1.9 2.3 ** 3.1 (mg/dL) WBC 56,300 2,800 3,700 ** ** 3,700 ** (mm³) **indicates test not performed Questions: 1. How would you explain the significant elevations of uric acid on admission? 2. Which two factors are responsible for the normal concentrations of uric acid seen in subsequent admissions? 3. Which is the most likely cause of the abnormally low concentration of urea nitrogen observed on 12/6? Which other laboratory test would confirm your suspicions?
A 3-year-old girl was admitted with a diagnosis of acute lymphocytic leukemia. After admission, she was treated by administration of packed red cells, 2 units of platelets, IV fluids, and allopurinol. On the second hospital day, chemotherapy was begun, using IV vincristine and prednisone and intrathecal injections of methotrexate, prednisone, and cytosine arabinoside. She was discharged for home care 5 days later. She was continued on prednisone and allopurinol at home. She received additional chemotherapy 1 month later (11/1) and again on 11/14. On 12/6, she was readmitted because she had painful sores in her mouth and was unable to eat. LABORATORY RESULTS 10/1 10/2 10/3 10/4 11/14 12/6 6/20 Urea N 12.0 ** ** 15 4.0 2.0 ** (mg/dL) Creatinine 0.7 (mg/dL) ** ** 1.0 0.7 ** 0.7 Uric acid 12.0 9.2 4.0 1.9 2.3 ** 3.1 (mg/dL) WBC 56,300 2,800 3,700 ** ** 3,700 ** (mm³) **indicates test not performed Questions: 1. How would you explain the significant elevations of uric acid on admission? 2. Which two factors are responsible for the normal concentrations of uric acid seen in subsequent admissions? 3. Which is the most likely cause of the abnormally low concentration of urea nitrogen observed on 12/6? Which other laboratory test would confirm your suspicions?
Chapter14: Allergy: An Overview
Section: Chapter Questions
Problem 19RQ
Related questions
Question
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution!
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
Recommended textbooks for you
Human Physiology: From Cells to Systems (MindTap …
Biology
ISBN:
9781285866932
Author:
Lauralee Sherwood
Publisher:
Cengage Learning
Human Physiology: From Cells to Systems (MindTap …
Biology
ISBN:
9781285866932
Author:
Lauralee Sherwood
Publisher:
Cengage Learning