A 44-year-old man develops temperatures to 38.3℃ (101℉), chills, malaise, and nausea 3 days after starting intravenous drug therapy for systemic candidiasis. His serum potassium concentration has decreased from 3.6 to 2.7 mEq/L, and serum creatinine concentration has increased from 1 to 2.5 mg/dL. Since he started the medication. This patient most likely received a drug with which of the following mechanisms of action? Decreases CYP450-dependent ergosterol synthesis. Decrease squalene epoxidase Increases ionic permeability of cell membrane Increases thymidylate biosynthesis Prevents mitosis by binding tubulin

A 44-year-old man develops temperatures to 38.3℃ (101℉), chills, malaise, and nausea 3 days after starting intravenous drug therapy for systemic candidiasis. His serum potassium concentration has decreased from 3.6 to 2.7 mEq/L, and serum creatinine concentration has increased from 1 to 2.5 mg/dL. Since he started the medication. This patient most likely received a drug with which of the following mechanisms of action? Decreases CYP450-dependent ergosterol synthesis. Decrease squalene epoxidase Increases ionic permeability of cell membrane Increases thymidylate biosynthesis Prevents mitosis by binding tubulin

Principles Of Pharmacology Med Assist

6th Edition

ISBN:9781337512442

Author:RICE

Publisher:RICE

Chapter4: The Metric System

Section: Chapter Questions

Problem 3RP

See similar textbooks

Similar questions

A 43-year-old woman with urinary tract infection received an intravenous antibiotic achieving a plasma level of 16 mg/L before the administration of second dose. If the half-life and the dosing interval are both 12 hours. Which of the following is the plasma concentration before the administration of the fourth dose? A 31 mg/L B 33 mg/L C 60 mg/L D 30 mg/L E 28 mg/L
A 71-year-old man with enterococci infection is started treatment with 240 mg of intravenous gentamicin. It has a volume of distribution of 30 L, a half-life of 4 hours, and demonstrates first-order and one-compartment kinetics. Which of the following is the most likely serum drug concentration 8 hours later? 0.5 mg/L 1 mg/L 1.5 mg/L 2 mg/L 3 mg/L
A patient received a single 245.97 mg IV bolus dose of an antibiotic and the plasma drug concentration was determined as 13.62 mg/L and 5.94 mg/L at 2.04 hours and 11.52 hours following the drug administration, respectively. On a separate occasion, a single 427.73 mg oral dose of the same antibiotic was administered to the same patient and the plasma drug concentration was determined as 0, 5.01, 5.77, 3.43, 1.1 mg/L at 0, 3.15, 7.69, 14.39, and 27.5 hours following the drug administration. Please calculate the bioavailability of this drug without utilizing any data fitting program.
A child who weighs 9 kg is prescribed nitrofurantoin at a dose of 1 mg/kg at night for prophylaxis against recurrent urinary-tract infections. How many mL of nitrofurantoin suspension 25 mg/5 mL should this child be given for each dose? Give your answer to one decimal place.
A male patient having a BMI of 35 was brought to the emergency department because of excessive frequent urination , drowsiness, vomiting, and diarrhea. Was on insulin daily until several days ago when he developed excessive thirst and frothy polyuria. For the past 3 days, he has also had headaches, myalgia, and a low grade fever. Diarrhea and vomiting began 1 day ago. The patient was advised some tests and the results were as follows Specific Gravity 1.012, Sodium 132 mEq/l, potassium 6 mEq/l pH 4.0, Alkaline Phosphatase 310 U/L, urine glucose +ve, Calcium 11 mg/dl, urine Acetone +ve, urine Protein +ve, FBS 560 mg/dl, urinary Oxalate +ve , GFR 55 ml/min, urine Acetoacetate +ve, BUN 31 mg/dL, Creatinine 3.2 mg/dL, Serum Ketones High, bicarbonate 15 mEq/l, Anion gap 13 Q:- Which lab results made you diagnose the above condition/s
Determine the maintenance dose (in mg) of tobramycin for a 65 year old male patient weighing 85 kg and measuring 5 ft 7, in. in height with a serum creatinine of 2.8 mg/dL. The loading dose desired is 1 mg/kg of ideal body weight and 1.8 mg/kg of ideal body weight for the maintenance dose. Report your answer as a whole number.
A 45-year-old man is being treated with oral levofloxacin for urinary tract infection. The plasma clearance of the drug is calculated as 15.0 L/h. Oral bioavailability of the drug is 75%. Sensitivity analysis of a sputum culture shows a minimal inhibitory concentration of 1 µg/mL for the causative pathogen. The target plasma concentration is 2 mg/L. If the drug is administered twice per day. Which of the following dosages should be administered at each dosing interval to maintain a steady state? (A)300 mg (B) 480 mg (C) 520 mg (D) 600 mg (E) 710 mg
Add 5 mL Sterile Water for Injection or Bacteriostatic Water for Injection to the 250 and 500 mgvials and administer slowly over a 3 to 5-minute period. Ampicillin for Injection, 1 g or 2 g, may alsobe given by direct intravenous administration. Dissolve in 7.4 or 14.8 mL Sterile Water for Injectionor Bacteriostatic Water for Injection, respectively, and administer slowly over at least 10 to 15minutes.c) What is the amount of diluent needed to reconstitute a 1 g vial of ampicillin for direct IV injectiond)What is the total amount of volume that will be removed from the vial and administered in aDirect Intravenous dose of 1g?
A drug has been developed for oral administration as a rapidly dissolving capsule. This drug is also available as an intravenous formulation. Pharmacokinetic studies with both formulations in a relevant patient population provided the following values for absorption rate constant, clearance, volume of distribution and bioavailability: ka = 1.0 h-1; Cl = 9 L/h; V = 90 L; and F = 0.8. Calculate the drug concentration (in the blood) 8 h after a 1000 mg dose is administered orally.
A patient taking ketoconazole, an antifungal agent, was also prescribed dofetilide to treat arrhythmias. The therapeutic window for dofetilide is 8–15 μg/mL. The patient’s serum levels are taken 48 hours after his first dose and his serum levels are 3 μg/mL. What is the cause of these reduced serum levels?
A mother observed that her 3-year-old male child started running at a temperature of 37.8 degrees celsius at night. The mother administered 5ml of paracetamol orally to the child with little effect; temperature 37.6 degrees celsius. She decided to continue to observe if the condition will improve, instead; by 2 pm the next day, the child started complaining of abdominal pain (scale of 5-6), vomiting, passed watery stool 4 times by 5;30 pm of the same day, Temperature 40 degrees celsius and seizures that lasted for 6 seconds. The child was rushed to the emergency department of your hospital. The child is being seen, examined and a series of tests carried out in order to establish a medical diagnosis. Dipstick urine test showed a high level of protein in the urine. Due to the critical condition of the child, the doctor ordered stat dose of the following medication: IM injection Baralgin 1ml, IM injection Diazapam 2.5mg, IV injection Ampiclox 125mg and IV infusion of 1/2 strength Dextrose…
In this case, a 72-year-old man with a medical history that includes hypertension, type 2 diabetes, coronary artery disease with stent implantation, and congestive heart failure is hospitalized for dyspnea while at rest. Despite salt restriction and diuretics, he continued to have swelling in his legs for four weeks. His L ejection fraction (EF) is 40 percent, which is excellent. Humalog (75/25) 20 units QD, furosemide 40 mg BID, metolazone 2.5 mg QD, spironolactone 12.5 mg QD, carvedilol 12.5 mg BID, ramipril 10 mg QD, atorvastatin 40 mg QD, clopidogrel 75 mg QD, and aspirin 81 mg QD are among the medications prescribed. The patient's blood pressure was 100/60 mmHg, his pulse was 102 beats/min, he had JVD, crackles, an S3, a positive hepatojugular reflex, and pitting edema that reached his knees. Na+ concentrations were 134 mEq/L, K+ concentrations were 3.8 mEq/L, Cl concentrations were 90 mEq/L, HCO3 concentrations were 28 mEq/L, BUN concentrations were 46 mg/dL, creatinine…