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Essentials of Pharmacology for Health Professions

Essentials of Pharmacology for Health Professions

7th Edition

ISBN:9781305441620

Author:WOODROW

Publisher:WOODROW

Chapter25: Cardiovascular Drugs

Section: Chapter Questions

Problem 23CRQ

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Question

A 74-year-old man is admitted with a myocardial infarction and a severe acute cardiac arrhythmia. You
decide to give lidocaine to correct the arrhythmia. A continuous intravenous infusion of lidocaine, 1.92
mg/min, is started at 8 AM. The pharmacokinetic parameters of lidocaine are: Vd 77 L; clearance 640
mL/min; half-life 1.4 h. What is the expected steady-state plasma concentration?
a.
40 mg/L
b.
0.025 mg/L
C.
3.46 mg/L
d.
7.2 mg/L
e.
3.0 mg/L

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