A crude extract sample was obtained from a plant and was found effective as an anti-diabetic agent in-vitro. The researcher wants to determine the appropriate lethal dose of the sample because it was intended to be administered orally. Literature studies show that plants under the same genus with the source of the crude extract has a lethal dose of 300 mg/Kg BW. Your group performed the test following the OECD Guideline 423 and used the recommended starting dose. The derived approximate LD50 was 25 mg/Kg BW. 1.With the approximate LD50 of the plant sample tested in the case, determine and interpret the TI of the sample if the ED50 is: A. 40 mg/Kg BW B. 18 mg/Kg BW C. 3 mg/Kg Bw
A crude extract sample was obtained from a plant and was found effective as an anti-diabetic agent in-vitro. The researcher wants to determine the appropriate lethal dose of the sample because it was intended to be administered orally. Literature studies show that plants under the same genus with the source of the crude extract has a lethal dose of 300 mg/Kg BW. Your group performed the test following the OECD Guideline 423 and used the recommended starting dose. The derived approximate LD50 was 25 mg/Kg BW. 1.With the approximate LD50 of the plant sample tested in the case, determine and interpret the TI of the sample if the ED50 is: A. 40 mg/Kg BW B. 18 mg/Kg BW C. 3 mg/Kg Bw
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter11: Genome Alterations: Mutation And Epigenetics
Section: Chapter Questions
Problem 8QP: Bruce Ames and his colleagues have pointed out that although detailed toxicological analysis has...
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A crude extract sample was obtained from a plant and was found effective as an anti-diabetic agent in-vitro. The researcher wants to determine the appropriate lethal dose of the sample because it was intended to be administered orally. Literature studies show that plants under the same genus with the source of the crude extract has a lethal dose of 300 mg/Kg BW. Your group performed the test following the OECD Guideline 423 and used the recommended starting dose. The derived approximate LD50 was 25 mg/Kg BW.
1.With the approximate LD50 of the plant sample tested in the case, determine and interpret the TI of the sample if the ED50 is:
- A. 40 mg/Kg BW
- B. 18 mg/Kg BW
- C. 3 mg/Kg Bw
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