A dose of 300 mg was administered to healthy volunteer. Five blood samples were colle at 0, 2, 4, 6, 8 hours. Plasma was separated from each blood sample and analyzed for d concentration. The collected data are shown in the table below. Determine the total A (mg.hr/L) Time (hr) Cp (mg/L) A(AUC mg.hr/L) AUC mg.hr/L 0 2 4 6 8 DO AAUC1-2 AAUC kel= = (Cp, +CP2)x(t, − t ) 2 = "last-00 4 3.1 2.6 2.3 2.1 CPlast kel In(CPfrom left on line) - In (CPfrom right on line) from right on line from left on line a) 110.67 mg.hr/L b) 68.8 mg.hr/L c) 10.34 mg.hr/L d) 7.86 mg.hr/L Hide question 5 feedback
A dose of 300 mg was administered to healthy volunteer. Five blood samples were colle at 0, 2, 4, 6, 8 hours. Plasma was separated from each blood sample and analyzed for d concentration. The collected data are shown in the table below. Determine the total A (mg.hr/L) Time (hr) Cp (mg/L) A(AUC mg.hr/L) AUC mg.hr/L 0 2 4 6 8 DO AAUC1-2 AAUC kel= = (Cp, +CP2)x(t, − t ) 2 = "last-00 4 3.1 2.6 2.3 2.1 CPlast kel In(CPfrom left on line) - In (CPfrom right on line) from right on line from left on line a) 110.67 mg.hr/L b) 68.8 mg.hr/L c) 10.34 mg.hr/L d) 7.86 mg.hr/L Hide question 5 feedback
Chapter23: Pediatric Intravenous Medications
Section: Chapter Questions
Problem 5SST
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Transcribed Image Text:A dose of 300 mg was administered to healthy volunteer. Five blood samples were collected
at 0, 2, 4, 6, 8 hours. Plasma was separated from each blood sample and analyzed for drug
concentration. The collected data are shown in the table below. Determine the total AUC
(mg.hr/L)
Time (hr) Cp (mg/L) A(AUC mg.hr/L) AUC mg.hr/L
0
2
4
6
8
DO
AAUC₁-2
=
AAUC last-00
kel=
=
(CP, +CP2)x(t - t)
2
CPlast
kel
4
3.1
2.6
2.3
2.1
In(CPfrom left on line) - In(CPfrom right on line)
from right on line from left on line
a) 110.67 mg.hr/L
b) 68.8 mg.hr/L
c) 10.34 mg.hr/L
d) 7.86 mg.hr/L
Hide question 5 feedback
kel = 0.045
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