A female patient has presented with the following results for spirometry and plasma Po2. What is your diagnosis? (You may need to look up the normal ranges for a female). Parameter Vital Capacity FEV₁ FVC Arterial Poz Venous Po2 COPD Value 2120 ml 1450 ml 1810 ml 87 mmHg 34 mmHg O Pulmonary fibrosis O Pulmonary oedema O Methemoglobinaemia (causes a leftward shift in the oxygen-haemoglobin dissociation curve)
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- A 30-year-old woman arrives at the outpatient department complaining of nausea and vomiting. The patient seems to have jaundice as well. Blood and urine tests are ordered in the laboratory. The following are the results collected from the testing: • Complete Blood Count o Hemoglobin:Normal o WBCcount:Normal • Serum Bilirubin o Total:7.0mg/dL o Conjugated:6.0mg/dL • Serum Enzymes o AlanineTransaminase(ALT):330U/L o AlkalinePhosphatase(ALP):195U/L • Urinalysis o Appearance:Darkbrown o Bilirubin:Positive o Urobilinogen:Decreased ANSWER THE FOLLOWING: 1. Interpret and correlate the patient’s laboratory results. 2. Discuss the possible causes of jaundice in this patient. 3. What part of the bilirubin pathway is severely affected? Explain. 4. What other serum enzyme/s can be used to assess the patient’s condition? Explain.With the results below, do you think the patient requires a transfusion? Using current guidlines to support your answer , explain your reason. Investigation Result (normal range - female) Haematology Red cell count (x 1012/L) 4.0 (3.8 – 5.8) Haemoglobin (g/L) 123 (115 – 165) White cell count (x 109/L) 8.1 (3.6 – 11.0) neutrophils 2.9 (1.8 – 7.5) lymphocytes 4.5 (1.0 – 4.0) monocytes 0.62 (0.2 – 0.8) eosinophils 0.10 (0.1 – 0.4) basophils 0.02 (0.02 – 0.1) Platelets (x 109/L) 138 (140 – 400) Prothrombin Time (s) 20 (10 – 14) Activated Partial Thromboplastin Time (s) 45 (22 – 36) Biochemistry Serum Bilirubin (µmol/L) 50 (≤21) Serum ALP (IU/L) 300 (30 – 130) Serum AST (IU/L) 527 (≤32) Serum ALT (IU/L) 650 (10 – 35) Serum albumin (g/L) 37 (35 – 50) Urine: Microscopy Faeces: Microscopy WBC <5 per ml No Cryptosporidium seen RBC <5…A 38-year-old white woman was treated in the emergency department for severe lacerations and abdominal injuries sustained in an automobile accident. She was admitted to the hospital for observation and further evaluation. On admission, a complete blood count (CBC), urinalysis, and radiograph series were ordered. Her CBC results were as follows: Hemoglobin 10.5 g/dL Hct 34% RBC 3.8 × 1012/L WBC 12.0 × 109 /L The RBC indices were as follows: MCV 89.6 fL MCH 27.6 pg MCHC 31 g/dL The peripheral blood smear showed essentially normal RBC morphology and platelet distribution. Forty-eight hours after admission, a stat repeat CBC was ordered. The results were as follows: Hemoglobin 8.0 g/dL Hct 26% RBC 2.9 × 1012/L WBC 15.5 × 109 /L The RBC indices were all within their normal ranges. A peripheral blood smear showed normal RBC morphology, although some polychromatophilia was noted. The distribution of platelets had increased. A follow-up platelet count was 0.60 × 1012/L. Subsequently,…
- A 38-year-old white woman was treated in the emergency department for severe lacerations and abdominal injuries sustained in an automobile accident. She was admitted to the hospital for observation and further evaluation. On admission, a complete blood count (CBC), urinalysis, and radiograph series were ordered. Her CBC results were as follows: Hemoglobin 10.5 g/dL Hct 34% RBC 3.8 × 1012/L WBC 12.0 × 109 /L The RBC indices were as follows: MCV 89.6 fL MCH 27.6 pg MCHC 31 g/dL The peripheral blood smear showed essentially normal RBC morphology and platelet distribution. Forty-eight hours after admission, a stat repeat CBC was ordered. The results were as follows: Hemoglobin 8.0 g/dL Hct 26% RBC 2.9 × 1012/L WBC 15.5 × 109 /L The RBC indices were all within their normal ranges. A peripheral blood smear showed normal RBC morphology, although some polychromatophilia was noted. The distribution of platelets had increased. A follow-up platelet count was 0.60 × 1012/L.…A 38-year-old white woman was treated in the emergency department for severe lacerations and abdominal injuries sustained in an automobile accident. She was admitted to the hospital for observation and further evaluation. On admission, a complete blood count (CBC), urinalysis, and radiograph series were ordered. Her CBC results were as follows: Hemoglobin 10.5 g/dL Hct 34% RBC 3.8 × 1012/L WBC 12.0 × 109 /L The RBC indices were as follows: MCV 89.6 fL MCH 27.6 pg MCHC 31 g/dL The peripheral blood smear showed essentially normal RBC morphology and platelet distribution. Forty-eight hours after admission, a stat repeat CBC was ordered. The results were as follows: Hemoglobin 8.0 g/dL Hct 26% RBC 2.9 × 1012/L WBC 15.5 × 109 /L The RBC indices were all within their normal ranges. A peripheral blood smear showed normal RBC morphology, although some polychromatophilia was noted. The distribution of platelets had increased. A follow-up platelet count was 0.60 × 1012/L.…A 12-weeks pregnant woman complains of inability to focus, fatigue, and shortness of breath. On a physical examination, she looks pale and weak. Laboratory results are as follows: Reticulocyte count: 1%, Hematocrit: 27%; Hemoglobin: 6.5 g/dL; MCV: 105 fL, MCHC: 32%. Does this patient need a transfusion? Justify your answer.
- A 12-weeks pregnant woman complains of inability to focus, fatigue, and shortness of breath. On a physical examination, she looks pale and weak. Laboratory results are as follows: Reticulocyte count: 1%, Hematocrit: 27%; Hemoglobin: 6.5 g/dL; MCV: 105 fL, MCHC: 32%. If the patient's transfusion reactions history suggests anaphylactic reactions, which blood component should be given? Justify your answer.BACKGROUND A 2-year-old black girl is being seen by the hematologist after her pediatrician found her to be severely anemic with splenomegaly and jaundice. Her mother gives a possible history of a “blood problem” in her family but doesn’t know for sure. Her hemoglobin electrophoresis was normal, and the complete blood count (CBC) revealed a normocytic anemia. The platelet and white blood cell counts are normal. On the peripheral smear, there are many bizarre erythrocytes, including spiculated cells. A diagnosis of pyruvate kinase deficiency is made. Pyruvate kinase deficiency (PKD) can be inherited in an autosomal recessive manner, which means that a child must inherit a gene with the disease-causing mutation from both parents in order for the disorder to be inherited. The PLKR gene regulates the synthesis of the pyruvate kinase enzyme, which is located in the liver and red blood cells. Pyruvate kinase deficiency (PKD) is a rare genetic disorder characterized by the premature…GIVE THE POSSIBLE VARIATIONS IN COLOR OF THE PLASMA WHEN PERFORMING HEMATOCRIT DETERMINATION AND STATE THE CORRESPONDING SIGNIFICANCE OF EACH. pls do not provide image for of answer, do not give handwritten answer
- A 66-year-old male patient with amyloidosis was admitted to the hospital with severe gastrointestinal bleeding. Admission laboratory data includes: Hgb 10 g/dL Hct 0.32 Platelet count: Adequate PT 45 sec APTT 95 sec Fibrinogen 400mg/dL Thrombin Time 5 sec PT 1:1 mix 13 sec APTT 1:1 mix 30 sec (4-12 sec) Rusell’s Viper venom time 55 sec (14-20 sec) Questions: Why both PT and APTT test are prolonged? What additional test should be done that would help in the diagnosis?A nine-year old boy with HbSS disease presents with pain in his right leg. The complete blood count shows: Hb 7.5 g/dl; WBC 25x10 /L; PLT 300x10 /L. The MOST appropriate investigation to aid with his diagnosis is: a. PT / PTTb. Reticulocyte countc. ESRd. ASOTDescribe the characteristics of each cell: Neutrophil, Eosinophil, Basophil, Monocyte, LymphocyteAssuming that you are conducting blood typing on a glass slide, draw all the possible blood type results in the ABO typing test. (There are four possible blood types)Make a table about the normal range of hemoglobin and hematocrit for both males and females.