A healthy couple had their first child affected by cystic fibrosis. Their next three sons were not affected by this disorder. The couple is expecting another child and wishes to know the probability (odds) that this child will be: Not affected if the three brothers are homozygous dominant. Not affected if three unaffected brothers were determined by DNA typing to be carriers. Not affected if she (he) has one affected and five unaffected sisters. Draw pedigree of the family described in c.

Human Anatomy & Physiology (11th Edition)
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A healthy couple had their first child affected by cystic fibrosis. Their next three sons were not affected by this disorder. The couple is expecting another child and wishes to know the probability (odds) that this child will be:

  1. Not affected if the three brothers are homozygous dominant.
  2. Not affected if three unaffected brothers were determined by DNA typing to be carriers.
  3. Not affected if she (he) has one affected and five unaffected sisters.
  4. Draw pedigree of the family described in c.
A healthy couple had their first child affected by cystic fibrosis. Their next three sons were not
affected by this disorder. The couple is expecting another child and wishes to know the probability
(odds) that this child will be:
Answer to a.
a. Not affected if the three brothers are homozygous dominant.
b. Not affected if three unaffected brothers were determined by DNA typing to be carriers.
c. Not affected if she (he) has one affected and five unaffected sisters.
d. Draw pedigree of the family described in c.
I
Odds
II
Prior probability
Conditional probability (normal)
Joint probability
Posterior Probability
CFTR/CFTR
1 2
2
CFTR/CFTR
+A
3
4 5
Not affected carrier
Affected
Transcribed Image Text:A healthy couple had their first child affected by cystic fibrosis. Their next three sons were not affected by this disorder. The couple is expecting another child and wishes to know the probability (odds) that this child will be: Answer to a. a. Not affected if the three brothers are homozygous dominant. b. Not affected if three unaffected brothers were determined by DNA typing to be carriers. c. Not affected if she (he) has one affected and five unaffected sisters. d. Draw pedigree of the family described in c. I Odds II Prior probability Conditional probability (normal) Joint probability Posterior Probability CFTR/CFTR 1 2 2 CFTR/CFTR +A 3 4 5 Not affected carrier Affected
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