A lipid bilayer was prepared from equal amounts of the following lipids: • 1-lauryl-2-palmitoylphosphatidylcholine • 1-myristoyl-2-linoleoylphosphatidylcholine Adding cholesterol to the lipid bilayer prepared above will most likely decrease bilayer fluidity increase bilayer fluidity have no effect on bilayer fluidity O destroy the bilayer
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- In a lipid bilayer, the of all the lipid molecules are sandwiched between all of the __________. a. hydrophilic tails; hydrophobic heads b. hydrophilic heads; hydrophilic tails c. hydrophobic tails; hydrophilic heads d. hydrophobic heads; hydrophilic tailsWhat properties define the phospholipids that make up the lipid bilayer? Select all that apply. A. Nonpolar, hydrophobic hydrocarbon tails B. Polar, hydrophilic phosphate heads C. Nonpolar, hydrophobic phosphate heads D. Polar, hydrophilic hydrocarbon tailsSome structures are held together by hydrophobic interactions. If those interactions were to break down, say for example the pressure exceeded the upper limit for the hydrophobic interactions that held the phospholipid bilayer together, would the structure be able to regain it's shape and functionality if the pressure decreased?
- Of the following cell membrane lipids, which one 1) prefers to reside in the inner leaflet (or inner half) of the membrane bilayer, AND 2) is not zwitterionic at physiological pH (7.4)? 1. SM (sphingomyelin) is inner-leaflet & NOT zwitterionic 2. PC (phosphatidylcholine) is inner-leaflet & NOT zwitterionic 3. PS (phosphatidylserine) is inner-leaflet & NOT zwitterionic 4. 2 of these 3 responses are correctIn general terms, what would you expect to be different about the permeability of a lipid bilayer made of phospholipids (modern cells) and a bilayer made of fatty acids (protocell)?When cross sectional area of the head group is greater than that of the acyl side chain, which of the following lipid aggregates formation is favored?a) Micellesb) Bilayerc) Liposomed) Myelin sheath
- When phospholipids are added to an aqueous environment (consisting mostly of water) the phospholipid molecules will spontaneously assemble into a phospholipid bilayer where the layers are held together by weak attractive forces between molecules. These structures are often seen in nature as cell and organelle membranes. _____________________________________________________________________________ 3. Which movement is more likely within a membrane, lateral movement or transverse (ie. flip-flop)? Why? 4. Which forces hold the phospholipid bilayer together?The approximate thickness of the phospholipid bilayer is 10A 1 micro M 50A 150A 1nMChoose all that aplly that are TRUE for the lipid bilayer:Negative mark is given to incorrect answer(s). a. The polar head groups of the bilayer are positively charged. b. Individual lipid molecules in one face (monolayer) of the bilayer cannot diffuse (flip-flop) to the other monolayer and must be catalyzed by a lipid transporter called flippase. c. The bilayer is stabilized by covalent bonds between neighbouring phospholipid molecules. d. Polar, but uncharged, compounds readily diffuse across the bilayer. e. Individual lipid molecules are free to diffuse laterally on the surface of the bilayer.
- Given the melting profile of a membrane bilayer consisting of (see attached diagrams)where R = palmitate (16:0), (see graph) where the x-axis is temperature in °C andthe y-axis is the degree of fluidity (highervalue means the membrane is morefluid), in what direction does the curveshift if:a. the palmitate were replaced with oleate (18:1)b. the palmitate were replaced with stearate (18:0)c. the choline head group is replaced with –OCH2 CH3The composition of a cell membrane is not uniform for all types of cells.Some cell membranes are more rigid than others. Rigidity is determinedby a variety of factors, one of which is the structure of the carbon chains in the phospholipids that comprise the membrane. One example of aphospholipid was drawn, and another, having C–C double bonds in its carbon chains, is drawn here. Which phospholipid would be present in the more rigid cell membrane and why?Several students in our class always sit together in the front row. Suppose this could be because (i) they really like each other or (ii) nobody else in our class wants to sit next to them. a) Which explanation holds for the assembly of a lipid bilayer? Explain your answer. b) If the lipid bilayer assembled for the opposite reason, how would its properties differ?