A molecular mechanism for suppression s+ Wild type Active protein complex s+ VAVA AVAVA First mutation Inactive m Second mutation acting as suppressor Active protein complex m Suppressor mutation alone Inactive FIGURE 6-19 A first mutation alters the binding site of one protein so that it can no longer bind to a partner. A suppressor mutation in the partner alters the binding site so that both proteins are able to bind once again. Modifiers As the the degree of expr - LE U

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter30: Protein Synthesis
Section: Chapter Questions
Problem 7P
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In Figure 6-19,
a. what do the square/triangular pegs and holes
represent?
b. is the suppressor mutation alone wild type in
phenotype?

A molecular mechanism for suppression
s+
Wild
type
Active protein
complex
s+
VAVA
AVAVA
First
mutation
Inactive
m
Second
mutation
acting as
suppressor
Active protein
complex
m
Suppressor
mutation
alone
Inactive
FIGURE 6-19 A first mutation alters the binding site of one
protein so that it can no longer bind to a partner. A suppressor
mutation in the partner alters the binding site so that both
proteins are able to bind once again.
Modifiers As the
the degree of expr
- LE U
Transcribed Image Text:A molecular mechanism for suppression s+ Wild type Active protein complex s+ VAVA AVAVA First mutation Inactive m Second mutation acting as suppressor Active protein complex m Suppressor mutation alone Inactive FIGURE 6-19 A first mutation alters the binding site of one protein so that it can no longer bind to a partner. A suppressor mutation in the partner alters the binding site so that both proteins are able to bind once again. Modifiers As the the degree of expr - LE U
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