(A) The literature reports that when alcohol 1 (see structure below) is treated with thionyl chloride in diethyl ether, the single product is (35,5S)-3- chloro-5-methylcyclohexene (2) (no enantiomer of diastereomer of 2 is formed). Explain by writing a detailed mechanism. Look at the solution to LC-39 (B) Using a mechanism, predict what single stereoisomer of 2 should form when pyridine is substituted for the diethyl ether. (C) Finally, predict mechanistically what additional stereoisomers of 3- chloro-5-methylcyclohexene should form when 1 is treated with Lucas reagent (ZnCl₂/H₂0 CI).
(A) The literature reports that when alcohol 1 (see structure below) is treated with thionyl chloride in diethyl ether, the single product is (35,5S)-3- chloro-5-methylcyclohexene (2) (no enantiomer of diastereomer of 2 is formed). Explain by writing a detailed mechanism. Look at the solution to LC-39 (B) Using a mechanism, predict what single stereoisomer of 2 should form when pyridine is substituted for the diethyl ether. (C) Finally, predict mechanistically what additional stereoisomers of 3- chloro-5-methylcyclohexene should form when 1 is treated with Lucas reagent (ZnCl₂/H₂0 CI).
Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter22: Reactions Of Benzene And Its Derivatives
Section: Chapter Questions
Problem 22.59P
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Can you make sure to include what the reactions follow SN1, SN2, SNi etc
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