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A) What type of regulatory enzyme is this? B) In what general type of cellular pathway does this enzyme participate? C) Which form of the enzyme is active – ERK2 or ERK2-P2? D) What does "P2" stand for? E) Ultimately (meaning "finally") what is the ultimate effect on cellular metabolism due to activation of thi enzyme?

A) What type of regulatory enzyme is this? B) In what general type of cellular pathway does this enzyme participate? C) Which form of the enzyme is active – ERK2 or ERK2-P2? D) What does "P2" stand for? E) Ultimately (meaning "finally") what is the ultimate effect on cellular metabolism due to activation of thi enzyme?

An Illustrated Guide To Vet Med Term
An Illustrated Guide To Vet Med Term
4th Edition
ISBN:9781305465763
Author:ROMICH
Publisher:ROMICH
Chapter18: Like Cats And Dogs
Section: Chapter Questions
Problem 23MC
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3. Study the image below to answer the questions. ERK2 ERK2-P2 A B C-term N-term B1LO C-term N-term aL16 B1 2LO 82 84 63 Ribbon- anoL16 Ribbon- L16 89 87 88 B6 C-loop Pe* PY185 FLip L16- Lip Loop 199-20 aL12 aF MKI IL14 2L14 ERK2 – green/gold - ERK2-P2 – blue/red A) What type of regulatory enzyme is this? B) In what general type of cellular pathway does this enzyme participate? C) Which form of the enzyme is active – ERK2 or ERK2-P2? D) What does "P2" stand for? E) Ultimately (meaning "finally") what is the ultimate effect on cellular metabolism due to activation of this enzyme?
Transcribed Image Text:3. Study the image below to answer the questions. ERK2 ERK2-P2 A B C-term N-term B1LO C-term N-term aL16 B1 2LO 82 84 63 Ribbon- anoL16 Ribbon- L16 89 87 88 B6 C-loop Pe* PY185 FLip L16- Lip Loop 199-20 aL12 aF MKI IL14 2L14 ERK2 – green/gold - ERK2-P2 – blue/red A) What type of regulatory enzyme is this? B) In what general type of cellular pathway does this enzyme participate? C) Which form of the enzyme is active – ERK2 or ERK2-P2? D) What does "P2" stand for? E) Ultimately (meaning "finally") what is the ultimate effect on cellular metabolism due to activation of this enzyme?
Expert Solution
Step 1

In the above diagram, the N-terminal domain(residues 1–109 and 320–358) is made up of β strands (green) largely and two helices, αL16 (magenta) and C(blue). 

The C-terminal domain (residues 110-319) is mostly helical (blue), has phosphorylation lip (red) and the MAP kinase insertion (magenta).

Also, the side chains Thr-183, p-Tyr-183, Tyr-185 and p-Tyr-185 can be seen.

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