Agonist Lipid bilayer G G - ATP active CAMP PDE AMP Phosphorylation of target proteins PKA active The illustration shows a G protein coupled receptor (GPCR) linked to a second messenger signalling pathway. The activated G protein causes an increase in levels of CAMP. (a) What is the name of the enzyme labelled as B?

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter32: The Reception And Transmission Of Extracellular Information
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Agonist
Lipid bilayer
B
G
G
АТР
active
CAMP
PDE
ÞAMP
Phosphorylation of
target proteins
РКА
active
The illustration shows a G protein coupled receptor (GPCR) linked to a second
messenger signalling pathway. The activated G protein causes an increase in
levels of CAMP.
(a) What is the name of the enzyme labelled as B?
(b) GPCRS can couple to different G proteins. Which class, from the
options Ga, G., G or G12/13, is the receptor shown here?
Explain where signal amplification can occur in this second
messenger pathway
(c)
Transcribed Image Text:Agonist Lipid bilayer B G G АТР active CAMP PDE ÞAMP Phosphorylation of target proteins РКА active The illustration shows a G protein coupled receptor (GPCR) linked to a second messenger signalling pathway. The activated G protein causes an increase in levels of CAMP. (a) What is the name of the enzyme labelled as B? (b) GPCRS can couple to different G proteins. Which class, from the options Ga, G., G or G12/13, is the receptor shown here? Explain where signal amplification can occur in this second messenger pathway (c)
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