Answered: Aldosterone is an important steroid…

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter19: The Peripheral Endocrine Glands

Section: Chapter Questions

Problem 2RE

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Aldosterone is an important steroid hormone that regulates water and salt balance. People with congenital adrenal hyperplasia suffer from “salt wasting” if not treated with hormone replacement therapy. Explain why a mutation in the 21-hydroxylase gene results in a deficiency in aldosterone and cortisol production. Use the name of the substrate, the enzyme and the product in your answer!

Cholesterol
Dihydro-
Progesterone D
Andro-
Testosterone
testosterone
stenedione
21-hydroxylase
Estradiol
Aldosterone
and cortisol

Expert Solution

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21 hydroxylase deficiency causes defective conversion of adrenal precursors to cortisol and, in some cases, to aldosterone, sometimes resulting in severe hyponatremia and hyperkalemia.

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