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- Many hormone systems regulate body functions through opposing hormone actions. Describe how opposing hormone actions regulate blood-glucose levels?All of the following molecules are involved in insulin signal transduction except a. IRS b. RAS c. ANF d. PIP3Discuss the following statement: “We wouldhave no idea today of the importance of insulin as a reg-ulatory hormone if its absence were not associated withthe human disease diabetes. It is the dramatic conse-quences of its absence that focused early efforts on theidentification of insulin and the study of its normal role inphysiology.”
- "We would have no idea today of the importance of insulin as a regulatory hormone if its absence were not associated with the human disease diabetes. It is the dramatic consequences of its absence that focused early efforts on the identification of insulin and the study of its normal role in physiology."Describe the probable effect in adipocytes of insulin-stimulated uptake of glucose into these cells.Name two proteins that are effectors of the insulin signaling pathway in adipocytes, liver, or muscle cells. Explain how these effector proteins address the conditions that triggered insulin release.
- Describe the process that results in the activation of multiple copies of PKBPKB in response to the binding of a single molecule of insulin to its receptor. Explain why insulin can stimulate the activation PKBPKBof but not the activation of PKPK.Insulin gives a signal to inactivate hormone-sensitive lipase by dephosphorylation. TRUE/FALSEGlucose regulation by insulin would be impaired by ablation of the ________. Islets of Langerhans the pancreas adrenal medulla thyroid gland adrenal cortex
- GluT transporters are responsible for passive transport of Glucose into the cell to yield G-6-P that cannot exit the cell; in liver cells this process is always regulated by insulin. True or FalseDiscuss, in terms of AMPK activity and GLUT4, how physical inactivity might lead to insulin resistance.In order to help Mike understand, explain how the rate of insulin release differs after consumption of simple andcomplex carbohydrates. You may choose to answer with words or a labeled diagram Now use your table to explain to Mike why elevated insulin levels are associated with heart disease.
