Based on these data, where would you MOST likely find toll-like receptor-XX (TLR-XX) among the following options? Justify WHY you selected that option.Your justification must be based on the data that are presented here, not the type of bacteria. A. On the cell surface B. In the endosome/ lysosome C. In the nucleus D. In the mitochondriaE. In the endoplasmic reticulum cytochalasin BKilled bacteria + cytochalasin Bkilled bacteriaLive bacteriaNo treatment0III.204060Amount of IL-2 Produced (mg)The graph shown above shows data generated byexposing TLR-XX-expressing macrophages toGram negative bacteria (Staph. sp.) that possesslipopolysaccharides (LPS) on their surface. Thesebacteria have been inactivated (killed) by heattreatment or added alive. These experimentaltreatments were performed in the presence orabsence of cytochalasin B, which is a chemicalthat prevents phagocytosis. Note that TLR-X +hypothetical tool-like receptor.

TLRs (Toll-like receptors) are immune cells that assist in the detection and response to infections.…

Answered: Based on these data, where would you…

Human Physiology: From Cells to Systems (MindTap Course List)

9th Edition

ISBN:9781285866932

Author:Lauralee Sherwood

Publisher:Lauralee Sherwood

Chapter12: Body Defenses

Section: Chapter Questions

Problem 6RE

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Question

Based on these data, where would you MOST likely find toll-like receptor-XX (TLR-XX) among the following options? Justify WHY you selected that option.Your justification must be based on the data that are presented here, not the type of bacteria.

A. On the cell surface

B. In the endosome/ lysosome

C. In the nucleus

D. In the mitochondria

E. In the endoplasmic reticulum

cytochalasin B
Killed bacteria + cytochalasin B
killed bacteria
Live bacteria
No treatment
0
III.
20
40
60
Amount of IL-2 Produced (mg)
The graph shown above shows data generated by
exposing TLR-XX-expressing macrophages to
Gram negative bacteria (Staph. sp.) that possess
lipopolysaccharides (LPS) on their surface. These
bacteria have been inactivated (killed) by heat
treatment or added alive. These experimental
treatments were performed in the presence or
absence of cytochalasin B, which is a chemical
that prevents phagocytosis. Note that TLR-X +
hypothetical tool-like receptor.

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