Calcium channel blockers are drugs used to treat people with high blood pressure. They mostly affect the smooth muscle in blood vessels. Why would blockage of calcium channels in these cells lead to a decrease in blood pressure.  These drugs also can affect the myocardial muscle of the hear, where they decrease the strength of myocardial contraction. Explain why they have this effect.  In some people, these drugs have a side effect of decreasing intestinal motility, but are not likely to have side effects of decreasing skeletal muscle contraction. Yet muscles in both places require calcium. Explain why side effects are more likely in intestine than in skeletal muscle.

Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Lauralee Sherwood
Chapter10: The Blood Vessels And Blood Pressure
Section: Chapter Questions
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  1. Calcium channel blockers are drugs used to treat people with high blood pressure.
    1. They mostly affect the smooth muscle in blood vessels. Why would blockage of calcium channels in these cells lead to a decrease in blood pressure. 
    2. These drugs also can affect the myocardial muscle of the hear, where they decrease the strength of myocardial contraction. Explain why they have this effect. 
    3. In some people, these drugs have a side effect of decreasing intestinal motility, but are not likely to have side effects of decreasing skeletal muscle contraction. Yet muscles in both places require calcium. Explain why side effects are more likely in intestine than in skeletal muscle.
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