Describe the changes that occur in each step of the mechanism. (The probable mechanism of action of chymotrypsin)

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter27: Metabolic Integration And Organ Specialization
Section: Chapter Questions
Problem 20P: Figure 27.3 illustrates the response of R (ATP-regenerating) and U (ATP-utilizing) enzymes to energy...
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Describe the changes that occur in each step of the mechanism. (The probable mechanism of action of chymotrypsin)
His 57
Asp 102
C=0
CH
Sor 195
...H-N.
Ni
Gly 193
c=0
...H-N,
(a) Enzyme-substrate complex
..•H-N.
N:
c=0
(b) First tetrahedral
Intermediate
His 57
CH-CH,
Asp 102
c=0
...H-N,
CH,
CH
Ser 195
(c) Acyl-enzyme
......t;N~
C=o*.HN
Gly 193
CH-CH,
c=0
CH
H
(d) Acyl-enzyme
CH-CH,
...H-N.
c=0
CH
(e) Second tetrahedral
Intermediate
H
HO-C=0
The Probaple Mechanism of
CH-CH,
Action of Chymotrypsin.
Es Scanned or scanner
In Enz,m-product
con
Transcribed Image Text:His 57 Asp 102 C=0 CH Sor 195 ...H-N. Ni Gly 193 c=0 ...H-N, (a) Enzyme-substrate complex ..•H-N. N: c=0 (b) First tetrahedral Intermediate His 57 CH-CH, Asp 102 c=0 ...H-N, CH, CH Ser 195 (c) Acyl-enzyme ......t;N~ C=o*.HN Gly 193 CH-CH, c=0 CH H (d) Acyl-enzyme CH-CH, ...H-N. c=0 CH (e) Second tetrahedral Intermediate H HO-C=0 The Probaple Mechanism of CH-CH, Action of Chymotrypsin. Es Scanned or scanner In Enz,m-product con
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