Case study 1 Melanoma A 50-year-old woman presented one year ago with a skin lesion, a biopsy was taken. and histological examination showed malignant melanoma. The patient had surgery to remove the lesion and appeared to be clear of the disease. The patient did not have targeted therapy at this stage. On year after surgery, she developed metastasis in the liver. Tumour biopsy confirmed melanoma and next generation sequencing analysis of the cancer genome was carried out. The results of the genomic analysis are included in the table below. The list of genomic variants produced using next generation sequencing. Chromosome Gene Function Zygosity ID COSV56056643 7934 COSV61684056 18921 COSV52662617 17p13 COSV104574314 16p13 BRAF SMAD4 TP53 AXIN1 Base change c.1799T>A missense Heterozygous missense Heterozygous c.1082G>A missense Heterozygous c.535C>T missense Heterozygous c.948G>A Amino acid change 1. Introduce the topic focusing on the molecular background of melanoma 2 p.V600E p.R361H p.H179Y p.G650S TASK You are required to analyse and interpret the genomic data linked to the case study and critically discuss how the genomic analysis would help in patient diagnosis and therapeutic management.
Case study 1 Melanoma A 50-year-old woman presented one year ago with a skin lesion, a biopsy was taken. and histological examination showed malignant melanoma. The patient had surgery to remove the lesion and appeared to be clear of the disease. The patient did not have targeted therapy at this stage. On year after surgery, she developed metastasis in the liver. Tumour biopsy confirmed melanoma and next generation sequencing analysis of the cancer genome was carried out. The results of the genomic analysis are included in the table below. The list of genomic variants produced using next generation sequencing. Chromosome Gene Function Zygosity ID COSV56056643 7934 COSV61684056 18921 COSV52662617 17p13 COSV104574314 16p13 BRAF SMAD4 TP53 AXIN1 Base change c.1799T>A missense Heterozygous missense Heterozygous c.1082G>A missense Heterozygous c.535C>T missense Heterozygous c.948G>A Amino acid change 1. Introduce the topic focusing on the molecular background of melanoma 2 p.V600E p.R361H p.H179Y p.G650S TASK You are required to analyse and interpret the genomic data linked to the case study and critically discuss how the genomic analysis would help in patient diagnosis and therapeutic management.
Surgical Tech For Surgical Tech Pos Care
5th Edition
ISBN:9781337648868
Author:Association
Publisher:Association
Chapter9: Surgical Pharmacology And Anesthesia
Section: Chapter Questions
Problem 9.5CS
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