Citrate synthase is regulated by another metabolite that has the opposite effect (i.e., stimulates citrate synthase). Choose the description of a condition where a positive regulator activates citrate synthase. Low [ATP/ADP] ratio. ADP is an allosteric activator of citrate synthase. High [citrate]. Citrate is a positive allosteric activator. High [NADH/NAD*] ratio. NADH is a positive allosteric activator. High [ATP/ADP] ratio. High ATP substrate levels favor product formation.

Anatomy & Physiology
1st Edition
ISBN:9781938168130
Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Chapter24: Metabolism And Nutrition
Section: Chapter Questions
Problem 15RQ: Acetyl CoA can be converted to all of the following except ________. ketone bodies fatty acids...
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In the presence of saturating amounts of oxaloacetate, the activity of citrate synthase from pig heart tissue shows a sigmoid dependence on the concentration of acetyl‑CoA. When succinyl‑CoA is added, the curve shifts to the right and the sigmoid dependence is more pronounced.

Activity (% of Vmax)
100F No
80
60
40
20
I
succinyl-CoA
Succinyl-CoA
added
1
20 40 60 80 100 120
[Acetyl-CoA] (um)
Transcribed Image Text:Activity (% of Vmax) 100F No 80 60 40 20 I succinyl-CoA Succinyl-CoA added 1 20 40 60 80 100 120 [Acetyl-CoA] (um)
Citrate synthase is regulated by another metabolite that has
the opposite effect (i.e., stimulates citrate synthase).
Choose the description of a condition where a positive
regulator activates citrate synthase.
Low [ATP/ADP] ratio. ADP is an allosteric
activator of citrate synthase.
High [citrate]. Citrate is a positive
allosteric activator.
High [NADH/NAD*] ratio. NADH is a positive
allosteric activator.
High [ATP/ADP] ratio. High ATP substrate levels
favor product formation.
Transcribed Image Text:Citrate synthase is regulated by another metabolite that has the opposite effect (i.e., stimulates citrate synthase). Choose the description of a condition where a positive regulator activates citrate synthase. Low [ATP/ADP] ratio. ADP is an allosteric activator of citrate synthase. High [citrate]. Citrate is a positive allosteric activator. High [NADH/NAD*] ratio. NADH is a positive allosteric activator. High [ATP/ADP] ratio. High ATP substrate levels favor product formation.
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