Complete the interrelated pathways by providing the neccesary metabolite, enzyme, reaction or metabolic pathway. Use abbreviations/acronyms (except for coenzyme)
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Complete the interrelated pathways by providing the neccesary metabolite, enzyme, reaction or
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- 1. Select the INCORRECT statement about Glutamate dehydrogenase : a. Catalyzes the removal of NH4+ into glutamate b.Catalyzes the incorporation of NH*4 into a-ketoglutarate c. Catalyzes the removal of NH*4 from glutamate C d. Catalyzes the incorporation of NH'4 into a-keto acidCHOOSE THE CORRECT LETTER 1.Which of the following enzymes catalyze the reaction involved in the production of FADHy in the Kreb's cycle?A. malate dehydrogenaseB. a-ketoglutarate dehydrogenaseC.isocitrate dehydrogenaseD. succinate dehydrogenase 2.Steric acid requires eight cycles of B-oxidation to be completely converted to acety/-CoA.A.TrueB. False10. The enzyme that involved in the catalysis from alpha-ketoglutarate to glutamate is A. Alpha-ketoglutarate dehydrogenase B. Glutamate dehydrogenase C. Glutamate synthase D. Glutamate synthetase give explanation for both correct and incorrect options asap
- 2. Order the following TCA cycle metabolites in the order they appear in the cycle. Not all answers will be used. 1. 2. 3. 4. choices: pyruvate, alpha ketogluterate, glucose-6-phosphate, lactate, aconitase, isocitrate, oxaloacetate, fumarate.CHOOSE THE CORRECT LETTER 1.What are the B-oxidation products of lauric acid (C12H2402), a major component of coconut oil?A.6 acetyl-CoA, 6 NADH, 6 FADH2B. 6 acetyl-CoA, 5 NADH, 5 FADH2C. 5 acetyl-CoA, 6 NADH, 6 FADH2D. 5 acetyl-CoA, 5 NADH, 5 FADH2 2.What is the mechanism of ATP synthesis in glycolysis?A. substrate level phosphorylationB. reductionC. oxidationD. oxidative phosphorylation 3.Which of the following enzymes need ATP as a substrate in the reaction?A.phosphoglycerate kinaseB. phosphofructokinaseC. pyruvate kinaseD.glyceraldehyde-3-phosphate dehydrogenaseDescribe the role of ethanol in cellular energy supply, the metabolism of ethanol (alcohol), the regulation of its metabolism and the disease conditions associated with its metabolism especially - hypoglycemia, ketoacidosis, hepatic steatosis, Vitamin deficiency, and acetaldehyde toxicity (you should feel free to discuss other diseases that are directly related to ethanol metabolism).
- CHOOSE THE CORRECT LETTER 1.Which of the following substrates is used in the first oxidation step of the Kreb's cycle to produce NAH and CO2?A. isocitrateB.a-ketoglutarateC. citrateD. succinyl-CoA 2.What is the reason for isomerization of citrate to isocitrate?A.The reaction converts a tertiary alcohol, which cannot easily be oxidized, to a secondary alcohol that can be oxidizedB. Isocitrate protects cells from the toxic effects of arsenite ion.C. The reaction is one major regulatory step for the citric acid cycle because it functions as a rate limiting step.D. Isocitrate is a substrate for a reaction that occurs spontaneously without enzymatic catalysis9. Ethanol is oxidized to acetaldehyde in the liver cytoplasm by _____. Select one: a. alcohol dehydrogenase b. alcohol carboxylase c. pyruvate carboxylase d. pyruvate kinaseA patient exhibiting all the symptoms of beriberi is placed on a thiamine-enriched diet; however, the symptoms do not disappear. Genetic screening suggests a defect in pyruvate dehydrogenase phosphatase. Briefly explain why the genetic defect caused beriberi symptoms andy why thiamine supplementation had no effect.
- 1.Enumerate the enzymes of the alpha ketoglutarate dehydrogenase complex and write its mechanism of actionIf 14CO2 (radioactive carbon) were incorporated into the TCA cycle via the Pyruvate Carboxylase reaction which of the following molecules would contain radioactive carbon? a. Oxaloacetate b. Citric Acid c. Isocitrate d. Alpha-ketoglutarate e. Succinyl-CoA f .Succinate g. Fumarate h. Malate1. Which of the following TCA cycle intermediates is also a metabolite in gluconeogenesis? a. Oxaloacetate b. Pyruvate c. Citrate d. Succinate e. Succinyl CoA