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- An oncologist ordered gr V of a medication. It is available in elixir form as gr XV per fl oz. A. How many fluid ounces should you pour for this patient? B. How many fl dram would this be? C. How many Tbsp would this be? D. How many tsp would this be?An oncologist ordered gr 5 of a medication. It is available in elixir form as gr 15 per fl oz. A. How many fl oz should you pour for this patient? B. How many fl dr would this be? C. How many Tbsp would this be? D. How many tsp would this be?Jonabel has started clopidogrel (Plavix) after experiencing a transient ischemic attack (TIA). What is the desired therapeutic effect of this drug?a. Anti-inflammatory and antipyretic effectsb. To reduce the risk of a stroke from a blood clotc. Analgesic as well as clot-dissolving effectsd. To stop clots from becoming emboliWhy letter b is the right answer and why the remaining letters are not correct
- Which drug factor will increase removal of drug through dialysis? a. High Molecular Weight b. High Lipophilicity c. High Hydrophilicity d. High Protein BindingThe biexponential equation for a two compartment model drug is C1,t = 50.0e-1.64t + 20.0e-0.147t. The drug is administered as a rapid IV bolus at t = 0. After 2.00 hours how many mg/l will the drug concentration in the central compartment be.A single dose of 300mg of drug is 63% bioavailable by the IM route. The same drug is 42% bioavailable by the oral route. How many 150mg tablets would need to be administered PO BID to achieve plasma levels comparable to the IM dose?
- The peak plasma concentration achieved after the first IV dose of drug X is 25 mg/L. The drug’s half-life is 3.5 hours, and it is administered every 12 hours. What will be the peak plasma concentration at steady state?Polymer nanoparticles, Microparticles and hydrogels have been developed for slow and sustained drug release for slow and sustained drug release application; mark all that apply below: 1)Drug release from hydrogels can be via (a) drug diffusion, (b) degradation of the polymeric matrix and (c) swelling 2) PLGA degrades to lactic acid and glycolic acid, which are not biocompatible 3) Drug release can be triggered through internal and external stimuli - I.e. by use of pH labile chemistries or external triggers 4) Burst release describes the initial faster release rates often observed in drug delivery system, which is then followed by sustained release 5) while burst release is observed with polymer nanoparticles, it is not observed from hydrogelsWhich of the following events cannot increase the bioavailability of a drug? A. Patients suffer from cirrhosisB. Patients suffer from diarrheaC. Switch to intravenous injection from oral administration D. Switch to sustained-release formulations E. Switch to formulation with carriers