Consider what you discovered about the types of mutations in questions 4 and 5. How could these types of mutations result in Alzheimer’s disease?

Biology 2e
2nd Edition
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark
Chapter15: Genes And Proteins
Section: Chapter Questions
Problem 27CTQ: Transcribe and translate the following DNA sequence (nontemplate strand): 5'- ATGGCCGGTTATTAAGCA-3'
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Consider what you discovered about the types of mutations in questions 4 and 5. How could these types of mutations result in Alzheimer’s disease?

Codon in
Codon in
Amino Acid
DNA template strand
MRNA
APP gene in individuals
3'-CAA-5'
5'-GUU-3'
valine
without Alzheimer's
disease
APP gene in individuals
with Alzheimer's disease
leucine
3'-GAA-5'
5'-CUU-3'
Transcribed Image Text:Codon in Codon in Amino Acid DNA template strand MRNA APP gene in individuals 3'-CAA-5' 5'-GUU-3' valine without Alzheimer's disease APP gene in individuals with Alzheimer's disease leucine 3'-GAA-5' 5'-CUU-3'
Codon in DNA
Codon in mRNA
Amino acid
template strand
APP gene in
individuals without
CAA
GUU
Valine (Val)
Alzheimer's disease
APP gene in
individuals with
CUA
GAU
Aspartate (Asp)
Alzheimer's disease
Transcribed Image Text:Codon in DNA Codon in mRNA Amino acid template strand APP gene in individuals without CAA GUU Valine (Val) Alzheimer's disease APP gene in individuals with CUA GAU Aspartate (Asp) Alzheimer's disease
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