✓ Correct At pll 7.2 the glutamic acid (Glu) side chain will carry a charge of -1 (at 3 pH units above the pK, for Glu the side chain will be almost fully ionized whereas the histidine (Hid) side chain will carry a charge of < 0.5 (at pH-PK, the charge on His would be 0.5 since pH 7.2 is above its pK, it will carry less (+) charge as it becomes more deprotonated). As the pll increase to 7.9, the charge on Glu will remain-1 and the charge on His will decrease thus, this salt bridge is predicted to become weaker as pll is raised from 72 to 79 Part B Antify your answer with calculations of partial charges on these amino acid side chains at pll- 7.2. (Hint: Consider lessons from Coulomb's law, and the Henderson Hasselbalch equation) Express your answers using two significant figures separated by a comma

✓ Correct At pll 7.2 the glutamic acid (Glu) side chain will carry a charge of -1 (at 3 pH units above the pK, for Glu the side chain will be almost fully ionized whereas the histidine (Hid) side chain will carry a charge of < 0.5 (at pH-PK, the charge on His would be 0.5 since pH 7.2 is above its pK, it will carry less (+) charge as it becomes more deprotonated). As the pll increase to 7.9, the charge on Glu will remain-1 and the charge on His will decrease thus, this salt bridge is predicted to become weaker as pll is raised from 72 to 79 Part B Antify your answer with calculations of partial charges on these amino acid side chains at pll- 7.2. (Hint: Consider lessons from Coulomb's law, and the Henderson Hasselbalch equation) Express your answers using two significant figures separated by a comma

Chemistry & Chemical Reactivity

9th Edition

ISBN:9781133949640

Author:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel

Publisher:John C. Kotz, Paul M. Treichel, John Townsend, David Treichel

Chapter16: Principles Of Chemical Reactivity: The Chemistry Of Acids And Bases

Section16.4: Acid-base Properties Of Salts

Problem 2RC

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