cyclic AMP (CAMP) and leads to the breakdown of glycogen to glucose, a major energy source for cells. But glycogen breakdown is only part of the fight-or-flight response that epinephrine brings about; the overall effect on the body includes an increase in heart rate and alertness, as well as a burst of energy. Given that caffeine blocks the activity of CAMP phosphodiesterase, propose a mechanism by which caffeine ingestion leads to heightened

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Author:Matthew Douglas, Jung Choi, Mary Ann Clark
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Chapter37: The Endocrine System
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10. SCIENTIFIC INQUIRY Epinephrine initiates a signal transduction pathway that produces
cyclic AMP (CAMP) and leads to the breakdown of glycogen to glucose, a major energy
source for cells. But glycogen breakdown is only part of the fight-or-flight response that
epinephrine brings about; the overall effect on the body includes an increase in heart rate
and alertness, as well as a burst of energy. Given that caffeine blocks the activity of CAMP
phosphodiesterase, propose a mechanism by which caffeine ingestion leads to heightened
alertness and sleeplessness.
Transcribed Image Text:10. SCIENTIFIC INQUIRY Epinephrine initiates a signal transduction pathway that produces cyclic AMP (CAMP) and leads to the breakdown of glycogen to glucose, a major energy source for cells. But glycogen breakdown is only part of the fight-or-flight response that epinephrine brings about; the overall effect on the body includes an increase in heart rate and alertness, as well as a burst of energy. Given that caffeine blocks the activity of CAMP phosphodiesterase, propose a mechanism by which caffeine ingestion leads to heightened alertness and sleeplessness.
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