Determine the pl for this synthesized pentapeptide: A-B-C-D-E Given that the pK values for the amino acids in the peptide are PKR Amino Acid pK₁ 1.83 2.21 2.63 2 1.7 A B C D E pK₂ 9.14 9.46 4.04 9.4 8.64 12.34 10.17 Give your answer to 2 places after the decimal. Assume the basic PKR are amino groups and the acidic PKR are carboxyl groups.
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- 1. Delineate the detailed regulatory mechanism of activation of protein kinase A (PKA) 2. A sequence of amino acids in a certain protein is found to be -Ser-Gly-Pro-Gly. What secondary structural element would you predict this sequence be a part of? Explain your answer.You have been given a mixture of lysine, histidine and cysteine. The isoelectric point of the amino acids are as follows:Histidine 7.64Lysine 9.74Cystenie 5.02Show how you will separate the mixture into the pure forms. State and describe any instrument that you will use to separate the components in the mixtureImagine the main chain of a protein bends back on itself, so that two amino acid residues R₁ and R₂ come close to each other. In the table below are four possibilities for what R₁ and R2 might be. In each case, decide whether a specific interaction could form between the residues. If a specific interaction could form, give the name of the interaction. R₁ R₂ specific interaction? name of specific interaction x yes alanine valine O no isoleucine asparagine ○ yes O no yes lysine glutamate ☐ O no yes threonine asparagine O no
- Imagine the main chain of a protein bends back on itself, so that two amino acid residues R, and R₂ come close to each other. In the table below are four possibilities for what R, and R₂ might be. In each case, decide whether a specific interaction could form between th residues. If a specific interaction could form, give the name of the interaction. R₁ R₂ specific interaction? name of specific interaction X 5 O yes valine phenylalanine hydrogen bonding O no O yes threonine tyrosine hydrogen bonding O no O yes lysine glutamate O no phenylalanine serine O yes О по O Explanation Check 3 W E R % 5 7 8 LLC. All Rights Reserved Terms of Use Privacy Comer G H K Z X V B N M alt H option cmd P H alt cmd opQuestion 2. While internal cysteine amino acid sidechains in proteins undergo oxidation to produce disulfide crosslinks that stabilize the protein structure after folding, solvent-exposed cysteine sidechains can remain in their reduced thiol form and serve as reactive nucleophiles (recall for instance Acyl Carrier Proteins involved in fatty acid biosynthesis or various oxidoreductase enzymes). The reactive thiol groups in proteins can be detected using Ellman's test, wherein the protein is reacted with a disulfide Ellman's reagent to form a new mixed disulfide and a 2-nitro-5-thiobenzoate (TNB) byproduct. Upon addition of base, TNB is deprotonated to form a dianion, which absorbs light in the visible region and can be detected using UV-Vis spectroscopy. Ellman's Reagent CO₂H -NO₂ internal disulfide crosslink O₂N- HO₂C SH solvent- exposed thiol UV Absorbance at 412 nm O₂N- -S TNB²- alkaline pH O₂N- SH HO₂C 2-nitro-5-thiobenzoate (TNB) -NO2 mixed disulfide CO₂H a) Provide a detailed…Determine the pl for this synthesized pentapeptide: A-B-C-D-E Given that the pK values for the amino acids in the peptide are Amino pK1 pK2 PKR 2.49 8.9 Acid A B 1.79 9.56 13.19 C 1.93 9.12 D 1.95 9.68 4.13 E 2.52 9.08 Give your answer to 2 places after the decimal. Assume the basic pKR are amino groups and the acidic pKR are carboxyl groups.
- The image below is a positive ionization mode Electrospray ionization-mass spectrum (ESI-MS) spectrum for a peptide, obtained using high resolution mass spectrometry. If ionization occurs through de-protonation (assuming that the mass of a proton is 1.0 Da), what is the neutral mass of the peptide, in Da? 627.271 627.604 100 - 627.938 628.271 628.604 628.938 627.0 628.0 629.0 mass/charge (m/z) 628.271 626.271 1878.813 O 1884.813 % AbundancePolypeptides are polymers of amino acids. Suppose that a long polypeptide chain can undergo a transition from a helical conformation to a random coil. Consider a mechanism for a helix–coil transition that begins in the middle of the chain:hhhh…⇌ hchh… hchh… ⇌ cccc… in which h and c label, respectively, an amino acid in a helical or coil part of the chain. The first conversion from h to c, also called a nucleation step, is relatively slow, so neither step may be rate determining. (a) Set up the rate equations for this mechanism. (b) Apply the steady-state approximation and show that, under these circumstances, the mechanism is equivalent to hhhh… ⇌ cccc….The amino acid histidine has ionizable groups with pKa values of 1.8, 6.0, and 9.2, as shown. COOH H₂N-CH | CH ₂ pH = CH lonizable -COOH group COO- H₂N-CH 1.8 pk₁ CH2 H -COO- CH -HisH+ COO- H₂N-CH 1 6.0 pk2 CH ₂ H H N -His CH -NH COO- H₂N-CH 1 9.2 pk₂ CH2 -NH₂ H -N CH A biochemist makes up 80 mL of a 0.11 M solution of histidine at a pH of 5.1. She then adds 60 mL of 0.10 M HCl. What is the pH of the resulting solution?
- identifying specific interactions between residues in a protein www-awu.aleks.com 00 Imagine the main chain of a protein bends back on itself, so that two amino acid residues R, and R, come close to each other. Here's what R looks like: CH- CH₂ CH₂ 0=0 NH₂ O yes X Could R, form a disulfide bond with R₂ at physiological pH, if R2 were the right kind of residue? O no If you said R, could form a disulfide bond with R₂, what would R₂ have to be? If there's only one possibility, write its 3-letter code. If there is more than one possibility, write the 3-letter code of any of them. Explanation Check PH LLC. All Rights Reserved Terms of Use Privacy Center 1 AccenseThe amino acid histidine has ionizable groups with pKa values of 1.8, 6.0, and 9.2, as shown. COOH H₂N-CH CH₂ H 2 -N H lonizable group 6.0 1.9 7.94 0.11 N H CH -COOH H₂N-CH | CH₂ H 2 N 1.8 COO- I pk₁ C H COO- CH -HisH+ H₂N-CH 6.0 COO- pk ₂. CH₂ H 2 H -His N CH COO™ H₂N-CH 9.2 pk 3 CH₂ H -N с H —NH — —NH, A biochemist makes up 95 mL of a 0.11 M solution of histidine at a pH of 5.1. She then adds 60 mL of 0.10 M HCI. What is the pH of the resulting solution? N CHImagine the main chain of a protein bends back on itself, so that two amino acid residues R, and R₂ come close to each other. In the table below are four possibilities for what R, and R₂ might be. In each case, decide whether a specific interaction could form between residues. If a specific interaction could form, give the name of the interaction. R₁ R₁₂ specific interaction? name of specific interaction X 5 O yes O valine phenylalanine 0 О по O yes threonine tyrosine 0 O no O yes lysine glutamate 0 O no O yes phenylalanine serine Π O no Explanation Check Vicoran Hill LLC. All Rights Reserved. Terms of Use Privacy Center