Does the drug have an amine here? I am confused. Can none of the nitrogrens become ionized? AzaareneNNCarbonylCH3MethylAmineNBenzene RingN-OF)Aryl FluorideRisperidone(Final Product)

This is Risperidone drug and it carry so many numbers of functional group. Functional groups are…

Answered: Does the drug have an amine here? I am…

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Does the drug have an amine here? I am confused. Can none of the nitrogrens become ionized?

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter18: Functional Derivatives Of Carboxylic Acids

Section: Chapter Questions

Problem 18.40P

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Question

Does the drug have an amine here? I am confused. Can none of the nitrogrens become ionized?

Azaarene
N
N
Carbonyl
CH3
Methyl
Amine
N
Benzene Ring
N-O
F)
Aryl Fluoride
Risperidone
(Final Product)

Definition Definition Organic compounds with a nitrogen atom having a lone pair of electrons on it. Amines are derived from ammonia (NH 3 ), wherein hydrogen atoms are substituted by an aryl or alkyl group.

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Oh okay. So that amine can be ionized. Under what conditions? Typically, at physiological pH, that amine would not be ionized. So when would it be ionized and where in the body does that happen? Can you give specific pKa values?

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