Explain why a-helices are most commonly observed in transmembrane protein sequences when the distance from one side of a membrane to the other can be spanned by significantly fewer amino acids in a B-strand conformation. Match the items in the left column to the appropriate blanks in the sentences on the right. Reset Help van der Waals forces The structure of an a-helix promotes within a stretch of amino acids, prevents and at the same time interactions with other important molecules involved in H-bond donors or H-bond in the form of acceptors In contrast, a B-strand would allow in a manner which may not be on a noncontiguous stretch of amino acids. Further, intramolecular H-bonding, which is necessary for maintaining the cell membrane stability of the would not occur in the structure of a B-strand. electron donors or acceptors contiguous H-bonding protein sequence ionic bonding allows

Explain why a-helices are most commonly observed in transmembrane protein sequences when the distance from one side of a membrane to the other can be spanned by significantly fewer amino acids in a B-strand conformation. Match the items in the left column to the appropriate blanks in the sentences on the right. Reset Help van der Waals forces The structure of an a-helix promotes within a stretch of amino acids, prevents and at the same time interactions with other important molecules involved in H-bond donors or H-bond in the form of acceptors In contrast, a B-strand would allow in a manner which may not be on a noncontiguous stretch of amino acids. Further, intramolecular H-bonding, which is necessary for maintaining the cell membrane stability of the would not occur in the structure of a B-strand. electron donors or acceptors contiguous H-bonding protein sequence ionic bonding allows

Biology Today and Tomorrow without Physiology (MindTap Course List)

5th Edition

ISBN:9781305117396

Author:Cecie Starr, Christine Evers, Lisa Starr

Publisher:Cecie Starr, Christine Evers, Lisa Starr

Chapter7: Gene Expression And Control

Section: Chapter Questions

Problem 2CT

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Show below is a polypeptide comprised of 3 α-helices and 5 β-sheets joined by randomcoil. Characterizetheforces that stabilize the tertiarystructure and draw the interacting side chains ofd) Cys Cys
Within a protein, certain amino acids are positively charged (e.g.,lysine and arginine), some are negatively charged (e.g., glutamateand aspartate), some are polar but uncharged, and some are nonpolar.If you knew that a DNA-binding protein was recognizingthe DNA backbone rather than a base sequence, which aminoacids in the protein would be good candidates for interacting withthe DNA?
The following are sequences from three different alpha helices found inhuman proteins: hBak(72-87): GQVGRQLAIIGDDINR hCB1(196-210): VTASFTASVGSLFLT hCB2(248-262): LVLAVLLICWFPVL Classify each of these three helices as either a) mostly hydrophobic, b)mostly hydrophilic, or c) amphipathic. Use the helical wheel to explainyour answers. Given the character of these helices, in which part of the protein wouldyou expect them to reside?
A DNA-binding protein recognizes the following double-strandedsequence:5′–GCCCGGGC–3′3′–CGGGCCCG–5′This type of double-stranded structure could also occur withinthe stem region of an RNA stem-loop. Discuss the structural differencesbetween RNA and DNA that might prevent the DNAbindingprotein from recognizing a double-stranded RNA molecule.
How is it that protein–protein interactions thatare too weak to cause proteins to assemble in solutioncan nevertheless allow the same proteins to assemble intocomplexes on DNA?
Would a chimeric translation system containing thelarge ribosomal subunit from E. coli and the small ribosomal subunit from yeast (a unicellular eukaryote) beable to function in protein synthesis? Explain why orwhy not.
The usual hydrophobic region of a membrane is around 30 Angstroms. Knowing this, about many amino acid residues would a transmembrane helix have?
a. Do any strands of nucleic acid exist in nature inwhich part of the strand is DNA and part is RNA?If so, describe when such strands of nucleic acidare synthesized. Is the RNA component at the 5′end or at the 3′ end?b. RNA primers in Okazaki fragments are usually veryshort, less than 10 nucleotides and sometimes asshort at 2 nucleotides in length. What does this facttell you about the processivity of the primaseenzyme—that is, the relative ability of the enzymeto continue polymerization as opposed to dissociatingfrom the template and from the molecule beingsynthesized? Which enzyme is likely to have a greaterprocessivity, primase or DNA polymerase III?
For transmembrane proteins, either single-pass or multi-pass, the membrane spanning part of the protein usually assumes which of the following motifs? βαβ αβα α-helix β-pleated sheet
Given a sequence of a DNA coding strand: 5’-ATGATTATCCTATAG-3’ What is the sequence and direction of the mRNA strand synthesized from this DNA?
Which of the three 20-amino-acid sequences listed below in the single-letter amino acid code is the most likely candidate to form a transmembrane region (α helix) of a transmembrane protein? Explain your answer.A. I T L I Y F G N M S S V T Q T I L L I SB. L L L I F F G V M A L V I V V I L L I AC. L L K K F F R D M A A V H E T I L E E S
Can someone please explain why SWSTSFS has trouble becoming alpha helix and KKWWTTQ does not?