FIGURE 13-22 Intagration of Hox and agmertation-protin inputa by a da-acting gulatory emant Lat: Ada-acting gatory damant of the Dgane govema the praon of Dpon in the abdomen by at of tranacption tactors ighe D praion ed odurta to the thora but not into the abdomen ina wid-tpe embryo. b- Mutatiora in thepective binding stus ahown dep oprion in vaiou patturra in the domen. Bnding a Sp. Soppy-panect Hot ard Hod, Lrabthor and Abdominal-A Ext. Extradertic En, Engalect H, Homothara. Data tom Gabalin a ME andR S Mann Dct intguion of ar and Segnaraton Ganainputs Duing Droophla Deveipmant"Natu 2004, 3- 13.4 Spatial Ragultion of Gane Epression in Devalopmant 493 Hox proteins and segmant-polarity proteins control appendage location CSACTING REGULATORY ELEMENT REPORTER-GENE EXPRESON AA A AS Wid ype Hox2 M TI 12 a Repredin AI-A ) Has mutation DerpredA- A A A S mutation M Depred I- 0 En muteton M In pAlA S En mutation Depre A-A m End, h mutetona M Depred in A-A

Anatomy & Physiology
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Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Chapter16: The Neurological Exam
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As shown in Figure 13-22, how many different transcription factors govern where the Distal-less (Dll) gene will
be expressed?

FIGURE 13-22 Intagration of Hox and agmertation-protin inputa by a da-acting
gulatory emant Lat: Ada-acting gatory damant of the Dgane govema the
praon of Dpon in the abdomen by at of tranacption tactors ighe D
praion ed odurta to the thora but not into the abdomen ina wid-tpe embryo. b-
Mutatiora in thepective binding stus ahown dep oprion in vaiou patturra
in the domen. Bnding a Sp. Soppy-panect Hot ard Hod, Lrabthor and
Abdominal-A Ext. Extradertic En, Engalect H, Homothara. Data tom Gabalin
a ME andR S Mann Dct intguion of ar and Segnaraton Ganainputs Duing
Droophla Deveipmant"Natu 2004, 3-
13.4 Spatial Ragultion of Gane Epression in Devalopmant
493
Hox proteins and segmant-polarity proteins control appendage location
CSACTING REGULATORY ELEMENT
REPORTER-GENE EXPRESON
AA A AS
Wid ype
Hox2
M TI 12 a
Repredin AI-A
) Has mutation
DerpredA-
A A A
S mutation
M
Depred I-
0 En muteton
M
In pAlA
S En mutation
Depre A-A
m End, h mutetona
M
Depred in A-A
Transcribed Image Text:FIGURE 13-22 Intagration of Hox and agmertation-protin inputa by a da-acting gulatory emant Lat: Ada-acting gatory damant of the Dgane govema the praon of Dpon in the abdomen by at of tranacption tactors ighe D praion ed odurta to the thora but not into the abdomen ina wid-tpe embryo. b- Mutatiora in thepective binding stus ahown dep oprion in vaiou patturra in the domen. Bnding a Sp. Soppy-panect Hot ard Hod, Lrabthor and Abdominal-A Ext. Extradertic En, Engalect H, Homothara. Data tom Gabalin a ME andR S Mann Dct intguion of ar and Segnaraton Ganainputs Duing Droophla Deveipmant"Natu 2004, 3- 13.4 Spatial Ragultion of Gane Epression in Devalopmant 493 Hox proteins and segmant-polarity proteins control appendage location CSACTING REGULATORY ELEMENT REPORTER-GENE EXPRESON AA A AS Wid ype Hox2 M TI 12 a Repredin AI-A ) Has mutation DerpredA- A A A S mutation M Depred I- 0 En muteton M In pAlA S En mutation Depre A-A m End, h mutetona M Depred in A-A
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