Because of oxygen and nutrient requirements, cells in a tissue must reside within 100 μm of a blood vessel. Based on this information, explain why many malignant tumors often possess gain-of-function mutations in one of the following genes: βFGF, TGF-α, and VEGF.

Because of oxygen and nutrient requirements, cells in a tissue must reside within 100 μm of a blood vessel. Based on this information, explain why many malignant tumors often possess gain-of-function mutations in one of the following genes: βFGF, TGF-α, and VEGF.

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter32: The Reception And Transmission Of Extracellular Information

Section: Chapter Questions

Problem 21P

See similar textbooks

Related questions

Q: Write short paragraphs explaining each of the following statements:(a) Natural selection chooses…

A: The process in which changes and adaption is done in the group of living organism is known as…

Q: Which of the following statements supports the idea that extinction is necessary? * A. to give way…

A: Extinction is a process in which organisms or the groups are completely wiped off from the Earth.…

Q: Match each of the statements below with the fibrous protein that mostly fits the description.…

A: Keratin is a hard protein compound present in the epidermis, hair, and nails that aids in the…

Q: An epidemic may be detected by observing

A: Endemic is used to describe diseases that spreads rapidly to a large number of people of a given…

Q: What is humanized mice ?

A: Introduction:- The transplantation of living cells, tissues, or organs from one species to another…

Q: The activation of a CD8-positive T lymphocyte requires presentation of antigen in association with…

A: CD8 positive T-cells are the cytotoxic T-cells of immune system which get activated when specific…

Q: Using tables 2.1 and 2.2 as references, fill out the following table. The first item is given as an…

A: Geological time scale Geological time scale is a representation of Earth's history.

Q: Analysis of DNA sequences for a particular locus among individuals within a population provides…

A: The order of the four basic building units that make up the DNA molecule - known as "bases" - is…

Q: Which of the following is NOT true concerning Transdeamination O Transamination forms glutamate in…

A: ANSWER;- All amino acids participate in transamination reactions. Explain;- All of the amino acids…

Q: butterfly wing bird wing un What is the function of each of these structures? How are they different…

A: Analogous are comparable attributes shared by two unique creatures as a result of convergent…

Q: meiosis

Q: Combining your knowledge of rates of diffusion with yourknowledge of muscle physiology, explain why…

A: Slow-twitch (Type I) fibres, which are characterised by muscles with lengthy contraction duration…

Q: The hemoglobin in mammalian blood is usually thought ofsimply as increasing the amount of O2 that…

A: Introduction :- Hemoglobin is a protein found in red blood cells that allows blood to transport…

Q: Discuss the eukaryotic transcription process and mention the enzymes and components needed in the…

A: Cell is the basic structural and functional unit of life. All cells contains nucleus within which…

Q: Influenza vaccines must be changed yearly because the amino acid sequence of the viral proteins…

A: DISCLAIMER : Since you have asked multiple question, we will solve the first question for you. If…

Q: What are first-generation methods (the Sanger technique and capillary electrophoresis) ?

A: Sequencing is a term used in biology and genetic to describe the process of determining the main…

Q: If a red-eye female fly is crossed with a red-eye male fly, could they produce offspring with white…

A: The red-eye colored allele of fly is dominant over the white-eyed allele. Let us consider, XR as…

Q: Do all reflexes require sensory inputs from the same muscle bundle?

A: Introduction Sensory input is the stimulation of a sense organ, causing a nerve impulse to travel to…

Q: READ THIS: Notice that natural selection does not refer to indiv Trequency of adaptive heritable…

A: Ecosystem balance, often known as "ecosystem homeostasis," is influenced by both factors that tend…

Q: Which of the following is NOT true regarding the alternative complement pathway? It can be triggered…

A: There are three types of complement pathways: Classical pathway Alternative pathway Lectin pathway

Q: Splicing regulatory (SR) proteins bind at exon to recruit U1snRNP and U2 snRNP during RNA splicing.…

A: There are few important points about splicing apparatus are as follows: The central component of…

Q: On a separate sheet of paper. A. Classify the Value of Biodiversity: Give the value of each organism…

A: INTRODUCTION Biodiversity is referring to the diversity of living organisms that are interdependent…

Q: 4. The newly synthesized DNA strand during replication was made from the 5' to 3' direction. 5. The…

Q: 11. Choose from the following types of inheritance and write in the 1st column which one is…

A: Inheritance Inheritance is the biological process from which the genetic material is transferred…

Q: Which division of meiosis (meiosis I or meiosis II) a. most resembles mitosis? b. cuts the…

A: a.Meiosis II. b. Meiosis I. TELOPHASE I. c. Meiosis I. TELOPHASE I. d.Meiosis I

Q: What can you do with a closed ecosystem in a container's habitat to create more biotic niches?

A: The ecosystem is made up of biotic and abiotic variables and interactions between these two factors…

Q: Ultraviolet radiation can cause purine and pyrimidine bases to cross-link. True false

A: Adenine and thymine are the purines which are smaller two-ringed bases, and the pyrimidines consists…

Q: Arthropod muscle fibers typically do not generate actionpotentials. Using your knowledge of their…

A: Introduction :- Most arthropods move by using their segmental appendages, and the exoskeleton and…

Q: One of the most widely used means of communication among insects is chemical communication. How do…

A: *pheromones are chemicals released by an organism to external environment which takes specific…

Q: Explain "Numerical taxonomy" briefly.

A: Introduction In this question we will explain the Numerical taxonomy.

Q: overlapping one another and amplifying themselves. Where do you expect to see bands of Primer dimer…

A: Primer dimers are commonly caused due to contamination of our DNA sample and can be observed as a…

Q: Please give the following information about biopharmaceutical technology. Definition of…

A: Here we provide you the information regarding the future perspective, challenges, and examples of…

Q: Turnover of RNA and protein helps to control gene expression by influencing the concentration of…

A: Gene expression is a process in which the genetic instructions of genes are utilized to manage…

Q: What is gene targeting? Give some examples of gene targeting?

A: Gene is a stretch of DNA in a chromosome which codes for a functional product either in the form of…

Q: xamine the pedigree. If individual I-1 is a carrier for the Robertsonian translocation leading to…

A: Down syndrome is characterised by a combination of phenotypic features that include mental…

Q: Which microevolutionary force typically changes genotype frequencies without changing allele…

A: The allele frequency shows the incidence of an allele or a gene variant in a population. Genotype…

Q: breast cancer.

A: 1. The pineal gland is a small endocrine gland present on the dorsal side of forebrain. This gland…

Q: Proof-reading during DNA replication refers to: * O removal of thymine dimers by by excision repair…

A: DNA polymerases are the enzymes that build DNA in cells. During DNA replication (copying), most DNA…

Q: b. what impact do warming temperatures have on the amount of snow in Alaska

A: Warming temperature can affect adversely and positively to the snow in Alaska. The details are as…

Q: Provde real exmaples of Public health strategies and campains of the prevalence of diabetes.

A: Diabetes can be described as condition in which blood glucose or blood sugar, becomes too high in…

Q: Which of the following is not one of the principles for creating an enriched environment? Human and…

A: Answer :- Option (A) is correct. - Human and non-human environment.

Q: Describe briefly the generation of the active form of the transcription factor NFAT. Include the…

A: Nuclear factor of activated T cells (NFAT) was first identified as a Ca 2+/calcineurin-regulated…

Q: What are the promises and future uses of research in archaea?

A: Bacteria are microscopic single-cell prokaryotic organisms found in the environment. They are…

Q: a thymine dimer formed after UV radiation would be best described as a base substitution a base…

A: Mutation is the change in DNA sequence. Mutations can occur due to exposure to ionising radiation or…

Q: Wolves recolonized a large area around Grand Teton National Park (GTNP) in the late 1990’s. Wolf…

A: A Population Growth (Gr) is calculated by subtracting the initial population from the final…

Q: 2. In a common eudicot pattern of development for the common bean in the figur the seed (1), then…

A: Various environmental factors have a significant role in the germination of a seed. Hence the study…

Q: HAZARD AND VULNERABILITY IDENTIFICATION AND ASSESSMENT OF MINING AFFECTING RIVER

A: Water pollution is the polluting of streams, rivers, lakes, seas, or groundwater by pollutants…

Q: Explaina about pseudopregnant mouse ?

A: Pseudopregnancy consists of two words "pseudo" which means false and "pregnancy" which means…

Q: What are some of the advantages and disadvantages of utilizing insects as experimental animals in…

A: In various toxicological studies such as in drug toxicity analysis etc. using an insect as an…

Q: 1. Compare and contrast the following systems in the squid, perch, earthworm, and frog. a. Digestive…

A: Digestive system *Squid takes food through their mouth without teeth but their hard beak helps to…

Question

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

SEE SOLUTION Check out a sample Q&A here

Step 1

VIEW

Step 2

VIEW

Step 3

VIEW

Step by step

Solved in 3 steps

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.

Similar questions

PDGF is encoded by a gene that can cause cancer when expressed inappropriately. why do cancers not arise at wounds in which PDGF is released from platelets?
why EGFR play a role in CRC and other cancer?
Why do cancer cells undergo EMT and MET? What are the cellular changes (expression or suppression of molecules) associated with EMT and MET? What does each change facilitate?
A tumor cannot grow to be very large without the development of new blood vessels (angiogenesis) to provide access to oxygen and nutrients. During the 1990s, it was discovered that Factor X stimulates the proliferation and migration of the cells that form blood vessels, thereby inducing the formation of new blood vessels. Factor X binds to specific receptor tyrosine kinases (RTKs) on the cell surface and causes the RTKs to dimerize and become active, initiating an intracellular signaling cascade that stimulates cell division and inhibits apoptosis. Many cancer cells secrete high levels of Factor X, and increased Factor X expression in a tumor is correlated with a poor medical outcome for the patient. Some evidence suggests that blocking Factor X-dependent signaling may prevent the formation of new blood vessels and lead to the death of immature blood vessels without disturbing mature blood vessels. You work for a biotechnology company that seeks to create anticancer drugs that…
''In the cellular regulatory pathways that controlcell growth and proliferation, the products of oncogenesare stimulatory components and the products of tumorsuppressor genes are inhibitory components.'' 'Is this statement true? Explain why or why not.
Explain why in cells that are genetically NF1–/–, basal levels of GTP-bound activated Ras are higher than normal and respond to growth factor stimulation by increasing rapidly to far higher levels.
Given the following scenario, indicate if this will ‘promote’ or ‘prevent’ cancer development: An over-expression of Bcl-2
Explain the mechanism of Warburg effect and how it benefits cancer cells? With this guide
Chemotherapeutic agents can promote apoptosis in cancer cells by these mechanisms except; Group of answer choices Downregulating MCL1 expression Increasing BCL-2 expression Increased p53 expression Increased BIM (BH-3) expression
Describe the mutational event that produces the MYC oncogene in Burkitt’s lymphoma. Why does the particular mechanism for generating oncogenic MYC result in a lymphoma rather than another type of cancer? Describe another mechanism for generating oncogenic MYC.
Which of the following modifications of the Epithelial Growth Factor Receptor (EGFR) would be proliferative of epithelial cells? multiple answers A. Mutation of active site residue responsible for tyrosine phosphorylation. B. Deletion of extracellular ectodomain C. Mutation in ectodomain that prevents binding of EGF D. Cell expresses EGF E. Mutation in promoter that increases expression of EGF receptor F. Dimerization of receptor without growth factor G. Mutation in EGFR promoter that decreases expression of receptor
Explain the mechanism of Warburg effect and how it benefits cancer cells