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- . At therapeutic range, theophylline follows linear pharmacokinetics. The average t1/2 is 3.4 hours, and the average volume of distribution is 30 L. What is the average clearance for theophylline assuming a one-compartment model?Present the rationale for clinical applications of niacin. What are major side effects?Calculate KI' of the inhibitor from the information given. All information may not be needed to calculate. K'm = (29Ki+1.45x10^-10)/Ki Vmax = 11.7 µMs-1 Kcat = 130 s^-1 Vo = 3.0 μMs-1 S = 10 μM Et = 0.09 µM Inhibitor Concentration = 5x10^-12
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