neurokinin-1 receptor antagonists known to inhibit the CYP3A4 enzyme. There is a potential drug drug interaction between lopinavir/ritonavir combination and aprepitant. Explain the potential pharmacokinetic consequences of the interaction on PK parameters of lopinavir and ritonavir following oral administration. AUC, apparent volume of distribution, clearance.

Curren'S Math For Meds: Dosages & Sol
11th Edition
ISBN:9781305143531
Author:CURREN
Publisher:CURREN
Chapter16: Adult And Pediatric Dosages Based On Body Surface Area
Section: Chapter Questions
Problem 5.4P
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neurokinin-1 receptor antagonists known to inhibit the CYP3A4 enzyme. There is a potential drug drug interaction between lopinavir/ritonavir combination and aprepitant. Explain the potential pharmacokinetic consequences of the interaction on PK parameters of lopinavir and ritonavir following oral administration. AUC, apparent volume of distribution, clearance.
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