Guanine, as it would appear at physiological pH, is shown below. One of the pKas of guanine, which results from the loss of a hydrogen (as a proton) at N7, is 2.4. What is the average, net charge of guanine when the pH equals 2.4? H- H N 'N Z3 N H H

Guanine, as it would appear at physiological pH, is shown below. One of the pKas of guanine, which results from the loss of a hydrogen (as a proton) at N7, is 2.4. What is the average, net charge of guanine when the pH equals 2.4? H- H N 'N Z3 N H H

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter20: Carboxylic Acids And Nitriles

Section20.4: Substituent Effects On Acidity

Problem 7P: Dicarboxylic acids have two dissociation constants, one for the initial dissociation into a...

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Question

H 12

Guanine, as it would appear at physiological pH, is shown below. One of the pKas of guanine, which
results from the loss of a hydrogen (as a proton) at N7, is 2.4. What is the average, net charge of
guanine when the pH equals 2.4?
H
8
H
N
N
9
5
4
6
1
N
H
H

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