  HbR is reported to have P50=14torr and a Hillcoefficient=1.2. Calculate ΔYO2 for a climber with HbR assuming that, at 14,000 ft (∼4300m), PO2=43mmHg in lungs and PO2=10mmHg in muscle capillaries.

Question

HbR is reported to have P50=14torr and a Hillcoefficient=1.2. Calculate ΔYO2 for a climber with HbR assuming that, at 14,000 ft (∼4300m), PO2=43mmHg in lungs and PO2=10mmHg in muscle capillaries.

Step 1

HbR refers to the hemoglobin in relaxed state that is; it is bound with a minimum of one oxygen molecule.

Fractional saturation of oxygen is given by the below formula where, YO2 is the fractional saturation of oxygen, n is the Hill coefficient, P50 is the partial pressure of oxygen at 50% and PO2 is the given partial pressure of oxygen.

Step 2

Calculate the YO2 when Hill co-efficient is 1.2, P50 is 14 torr and PO2 is 43 mm of Hg in lungs at 14,000 ft in the given equation.

Step 3

Calculate the YO2 when Hill co-efficient is 1.2, P50 is 14 torr and PO2 is 10 mm of Hg...

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