Holding Potential (mV) Measured Current (pA) -100 -1.0 -50 0.0 0 +1.0 +50 +2.0 +100 +3.0
Patch clamp recording of a single ion channel yields the following results:
Holding Potential (mV) |
Measured Current (pA) |
-100 |
-1.0 |
-50 |
0.0 |
0 |
+1.0 |
+50 |
+2.0 |
+100 |
+3.0 |
part a.) Calculate the membrane potential at the instant when a neuron has the following relative permeabilities: PK+ = 1.0, PNa+ = 1.0, PCl- = 1.0. Use the ionic concentration values in the picture included.
a.) -12 mv
b.) -35mv
c.) -60 mv
d.) +20 mv
e.) 0 mv
part b.) What would be the equilibrium potential for K+ in neurons under such circumstances?
a.) -11 mv
b.) +30 mv
c.) +75 mv
d.) -35 mv
e.) 0 mv
part c.)
What would be the new resting potential, discounting the effects of non-gated chloride channels (just give an approximate value – no calculation is necessary)?
![lon concentration gradients
Na
cr)
(Cr)
K*
A
Na
Na
A
K*
(Cr
(cr
(Cr)
Na Na (Cr)
A
+
K*
K*
A
Cr
Nat
(Cr)
Na
Na СГ
A
K+
A
+
K*
K+
Na
A
Na
K*
K*
(Cr) Na
A A
K*
(СГ
(Cr)
A
A
Na
(Cr)
K*
K+
A
СГ
Na
Na (Cr)
(A)
Na
(Cr
A) K
K+
K™
A
A
(Cr)
Na
Na
A
K
K
extracellular
sodium (Na*): 144 mM
chloride (CI): 144 mM
potassium (K*): 5 mM
calcium (Ca): 1 mM
inorganic anions (A¹): 0 mM
intracellular
potassium (K): 100 mM
organic anions (A¹): 100 mM
sodium (Na): 16 mM
chloride (CI¯¹): 13 mM
calcium (Ca¹2): 0.0001 mM](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F9066a9c6-3f69-452f-96ca-c7078db7954f%2F23fa370c-3180-4df5-97a3-becb9f851432%2Fhcrcguh_processed.png&w=3840&q=75)
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