How can an extracellular bacterium and an intracellular virus independently be targeted by a particular T cell response? And what is the mechanism of antigen presentation
How can an extracellular bacterium and an intracellular virus independently be targeted by a particular T cell response? And what is the mechanism of antigen presentation?
Cytotoxic T cells and Helper T cells provide protection against differen types of pathoges.
Immature T cells that have yet to encounter an antigen first are converted into activated effector T cells, when they come in contact with Antigen Presenting cells (APCs).
These APCs, such as macrophages, dendritic cells and B-cells in some circumstances, load antigenic peptides onto the Major histocompatibility Complex(MHC) of the cell, in turn presenting the peptide to receptors on T cells.
Now these Activated effector T cells can be placed into different functioning classes
Some Activated effector T cells detect peptide antigens that originate from various types of pathogens
1) Cytotoxic T cells which kill infected target cells by apoptosis without using cytokines,
2) Thi cells primarily function to activate macrophages,
3) Th 2 cells which primarily function to stimulate B cells to produce antibodies.
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