How is the DNA unwound at the replication fork? What effect does this have on the DNA upstream of the fork, and how does the cell deal with this effect?  b. Sliding clamps are topologically-closed rings that can encircle the DNA double helix. How, then, are they able to get on and off the DNA? What purpose is served by this striking topology?

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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  1. How is the DNA unwound at the replication fork? What effect does this have on the DNA upstream of the fork, and how does the cell deal with this effect?  b. Sliding clamps are topologically-closed rings that can encircle the DNA double helix. How, then, are they able to get on and off the DNA? What purpose is served by this striking topology?
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