I need help on 6 and 7 please 3. Histidine possesses a basic side chain which is protonated at physiological pH, Identifywhich nitrogen atom in the side chain is protonated (Show the structure of Histidine).4. Draw the bond-line structure of the peptide that corresponds with the following sequenceof amino acid residues and identify the N terminus and C terminus:Trp-Val-Ser-Met-Gly-Glu5. Show all the steps necessary to make the dipeptide Phe-Ala from L-phenylalanine andLalavine.6. Predict the major product of the reaction between L-valine and:а. МеОН, Н'b. Di-tert-butyl-dicarbonate.с. NaOH, H2Od. HCI7. Draw the structure of the protected amino acid that must be anchored to the solid supportin order to use a Merrifield synthesis to prepare leucine encephalin.(N terminus)Try-Gly-Gly-Phe-Leu(С Тегminus)

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Science

Chemistry

I need help on 6 and 7 please

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter26: Biomolecules: Amino Acids, Peptides, And Proteins

Section26.SE: Something Extra

Problem 54AP

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I need help on 6 and 7 please

3. Histidine possesses a basic side chain which is protonated at physiological pH, Identify
which nitrogen atom in the side chain is protonated (Show the structure of Histidine).
4. Draw the bond-line structure of the peptide that corresponds with the following sequence
of amino acid residues and identify the N terminus and C terminus:
Trp-Val-Ser-Met-Gly-Glu
5. Show all the steps necessary to make the dipeptide Phe-Ala from L-phenylalanine and
Lalavine.
6. Predict the major product of the reaction between L-valine and:
а. МеОН, Н'
b. Di-tert-butyl-dicarbonate.
с. NaOH, H2O
d. HCI
7. Draw the structure of the protected amino acid that must be anchored to the solid support
in order to use a Merrifield synthesis to prepare leucine encephalin.
(N terminus)
Try-Gly-Gly-Phe-Leu
(С Тегminus)

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