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- MHC class I molecules present peptide antigens derived from a(n) _______ compartment, whereas MHC class II molecules present peptide antigens derived from a(n) _______ compartment: a. extracellular; intracellular b. intracellular; extracellular c. opsonization; neutralization d. neutralization; opsonization e. none of the above.Identify which of the following statements regarding peptide–MHC molecule interactions are correct. (Select all that apply.) a. Peptides with different amino acid sequences may be able to bind to the same type of MHC molecule. b. Covalent bonds hold the peptide in the groove of the MHC molecule. c. The length of peptides bound by MHC class I molecules is shorter than that of those bound by MHC class II molecules. d. The groove of the MHC molecule is deep enough to accommodate two or more peptides. e. Binding pockets of MHC molecules anchor the side chains of only certain amino acids of the peptide. f. The amino- and carboxy-terminal amino acids of peptides are used for binding to MHC class I molecules, whereas amino acids along the length of the peptide are used for binding to MHC class II molecules. g. Only non-self peptides form stable interactions with MHC molecules. h. The type of MHC molecule presenting a non-self protein is informative regarding whether the…Identify the cells that display MHC class I and MHC class IIproteins on their surfaces
- In regard to antigen presentation, MHC class I molecules usually present peptides derived from _____, whereas MHC class II molecules usually present peptides derived from _____. a. intracellular cytosolic sources; vesicular system b. phagolysosome; proteasomes c. MIIC; self proteins d. CLIP; HLA-DM e. endocytic vesicles; endoplasmic reticulum.MHC class II proteins: A. present exogenous antigen to the immune system B. both are found on antigen presenting cells and present exogenous C. antigen to the immune system are found on antigen presenting cellsMHC class I proteins: A. both are on all nucleated cells and present endogenous antigens to the immune system B. present endogenous antigens to the immune system C. are on all nucleated cells
- What is the appropriate response when antigen is presented on MHC class II molecules?a) An effector CD8 cell should kill the presenting cell.b) An effector CD4 cell should kill the presenting cell.c) An effector CD8 cell should activate the presenting cell.d) An effector CD4 cell should activate the presenting cell.Match the appropriate term on the left with the appropriate definition of the right Pathogen-Associated Molecular Pattern MCH II MHC I Pattern Recognition Receptor A. A large macromolecule produced by pathogens which is unlike any macromolecule produced by the host B. An immune molecule which displays proteins from phagocytosed pathogens on the immune cell surface C. An immune molecule which displays normal cell proteins or proteins from intracellular pathogens on the surface of any host cell D. An immune receptor which recognizes macromolecules produced by broad classes of pathogensDescribe the six steps in antigen processing and presentation via the class I MHC pathway.
- About Antigen presenting cells, it is CORRECT to affirm that: a). Macrophages, B lymphocytes and dendritic cells are APCs. meaning they express MHC-ll. b). Only APCs present MHC-11. c). Macrophages,B lymphocytes and dendritic cells are phagocytes, but not APCs.d). All the non-APC cells of our body present MHC-1.Write T if the statement is correct; write F if the statement is not correct. Interferons enhance antigen presentation. " " Peptides that bind to MHC class II molecules are longer than those that bind MHC class I molecules. " " MHC molecules that lack a bound peptide is unstable. " " MHC class I:peptide:TCRcomplexes and MHC class II:peptide:TCR complex shows very similar orientation. " " The Golgi apparatus is part of the endomembrane system. " "Peptide editing is an important component of antigen presentation for both MHC class I and MHC class II pathways, as it drives the preferential presentation of high-affinity binding peptides. For MHC class II peptide editing, HLA-DM plays a key role. In the absence of HLA-DM: MHC class II molecules traffic to the cell surface with CLIP in their binding sites. No MHC class II molecules are released to traffic to the cell surface. MHC class II molecules bind to HLA-DO and are inhibited from binding peptides. Pathogens can evade the immune system by blocking peptide exchange on MHC class II. HLA-DO competes for high-affinity binding peptides with MHC class II molecules and blocks antigen presentation.